ArticleAngewandte Chemie (International ed. in English)2022
HFIP Mediates a Direct C-C Coupling between Michael Acceptors and Eschenmoser's salt.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Eschenmoser's salts: from design to applications in organic synthesis.Organic chemistry frontiers : an international journal of organic chemistry · 2026Review
- Hexafluoroisopropanol-Promoted Stereospecific Glycosylation Enables Efficient Access to N-O-Linked 1,2-JACS Au · 2025Article
- Iodide Anion Enables a Reductive Cross-Electrophile Coupling for Preparing Tertiary Amines.Angewandte Chemie (International ed. in English) · 2025Article
- Lewis Base-assisted Arylation of Unsaturated Carbonyls.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- The Eschenmoser's Salt as a Formylation Agent for the Synthesis of Indolizinecarbaldehydes and Their Use for Colorimetric Nitrite Detection.Angewandte Chemie (International ed. in English) · 2023Article
- HFIP Mediates a Direct C-C Coupling between Michael Acceptors and Eschenmoser's salt.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A direct C-C coupling process that merges Michael acceptors and Eschenmoser's salt is presented. Although reminiscent of the Morita-Baylis-Hillman reaction, this process requires no Lewis base catalyst. The underlying mechanism was unveiled by a combination of kinetic, isotopic labelling experiments as well as computational investigations, which showcased the critical role of HFIP as a superior mediator for proton-transfer events as well as the decisive role of the halide counterion.
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Registered trials
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