Evidence map›Paper›PMID 34813042›Full record

ReviewCurrent nutrition reports2021

Impact of COVID-19 on the Intestinal Microbiome.

Carla Venegas-Borsellino, Senthilkumar Sankararaman, Keelin Roche, JBracken Burns, Ryan Michael Landis

Open access · bronzeAbstract readReview
In one paragraph

Review in Current nutrition reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Carla Venegas-BorsellinoDepartment of Critical Care Medicine, Mayo Clinic, 4500 San Pablo Road Jacksonville, Jacksonville, FL, 32224, USA. Venegas-Borsellino.Carla@mayo.edu.ORCID 0000-0002-4323-2771
Senthilkumar SankararamanDepartment of Pediatrics (Pediatric Gastroenterology, UH Rainbow Babies & Children's Hospital, Hepatology & Nutrition), Cleveland, OH, USA.
Keelin RocheDepartment of Surgery (Trauma Surgery, Critical Care & Acute Care Surgery), East Tennessee State University, Johnson City, TN, USA.
JBracken BurnsDepartment of Surgery (Trauma Surgery, Critical Care & Acute Care Surgery), East Tennessee State University, Johnson City, TN, USA.
Ryan Michael LandisDepartment of Surgery (Trauma Surgery, Critical Care & Acute Care Surgery), East Tennessee State University, Johnson City, TN, USA.
East Tennessee State University · USJacksonville College · USRainbow Babies & Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review article aims to explore the GI changes induced by SARS-CoV-2 and how gut microbial homeostasis can influence these changes and affect the lung-gut axis and its relationship with the induction of the cytokine release syndrome in severe COVID-19 patients. RECENT

findingsCoronavirus disease 2019 (COVID-19) affects not only the respiratory system but can produce multi-systemic damage. The expression of angiotensin-converting enzyme 2 (ACE-2) receptors in the gastrointestinal (GI) tract, the high prevalence of GI symptoms in severely ill COVID-19 patients, and the abnormalities described in the gut microbiome in these patients have raised concerns about the influence of GI tract as a risk factor or as a potential modulator to reduce the severity of COVID-19. Understanding the mechanisms by which gut dysbiosis may influence viral transmission and disease progression in COVID-19 may help in shaping how accessible therapies, like diet modulation, can potentially help beat the devastating consequences of COVID-19.

Indexed as

COVID-19Gastrointestinal MicrobiomeDysbiosisGastrointestinal TractHumansSARS-CoV-2Brain-gut axisCOVID-19Cytokine release syndromeGastrointestinal manifestationsMicrobiomeProbioticsSARS-CoV-2

Identifiers

PMID34813042
PMCPMC8609508
OpenAlexW3214756787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.