Evidence map›Paper›PMID 34813040›Full record

ArticleCerebellum (London, England)2022

Consensus Paper: Novel Directions and Next Steps of Non-invasive Brain Stimulation of the Cerebellum in Health and Disease.

Mario Manto, Georgios P D Argyropoulos, Tommaso Bocci, Pablo A Celnik, Louise A Corben, Matteo Guidetti, Giacomo Koch, Alberto Priori, John C Rothwell, Anna Sadnicka and 4 more

Registry-linked trialOpen access · bronzeAbstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in Cerebellum (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07548801 (Can Cerebellar Transcranial Direct Current Stimulation be Regarded as a Rational Therapeutic Option for Treating Parkinson's Disease ?), which is not on this map. Cited by 48 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 6 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07548801 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Can Cerebellar Transcranial Direct Current Stimulation be Regarded as a Rational Therapeutic Option for Treating Parkinson's Disease ?

TypeinterventionalSponsorUniversité Libre de BruxellesRan2025 to 2026Enrolled25ConditionsPARKINSON DISEASE (Disorder)ArmscTDCS
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 6 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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  19. Hypnotizability and Time Reproduction.Cerebellum (London, England) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 7 countries.

Mario MantoService de Neurologie, CHU-Charleroi, 6000, Charleroi, Belgium.
Georgios P D ArgyropoulosDivision of Psychology, Faculty of Natural Sciences, Faculty of Natural Sciences, University of Stirling, Stirling, FK9 4LA, UK.
Tommaso BocciAldo Ravelli Research Center for Neurotechnology and Experimental Neurotherapeutics, Department of Health Sciences, University of Milan, 20142, Milan, Italy.
Pablo A CelnikDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Louise A CorbenBruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Department of Paediatrics, University of Melbourne, Parkville. Victoria, Australia.
Matteo GuidettiAldo Ravelli Research Center for Neurotechnology and Experimental Neurotherapeutics, Department of Health Sciences, University of Milan, 20142, Milan, Italy.
Giacomo KochFondazione Santa Lucia IRCCS, via Ardeatina 306, 00179, Rome, Italy.
Alberto PrioriAldo Ravelli Research Center for Neurotechnology and Experimental Neurotherapeutics, Department of Health Sciences, University of Milan, 20142, Milan, Italy.
John C RothwellDepartment of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, London, UK.
Anna SadnickaMotor Control and Movement Disorders Group, St George's University of London, London, UK.
Danny SpampinatoFondazione Santa Lucia IRCCS, via Ardeatina 306, 00179, Rome, Italy.
Yoshikazu UgawaDepartment of Human Neurophysiology, Fukushima Medical University, Fukushima, Japan.
Maximilian J WesselDefitech Chair of Clinical Neuroengineering, Center for Neuroprosthetics (CNP) and Brain Mind Institute (BMI), Swiss Federal Institute of Technology (EPFL), Geneva, Switzerland.
Roberta FerrucciAldo Ravelli Research Center for Neurotechnology and Experimental Neurotherapeutics, Department of Health Sciences, University of Milan, 20142, Milan, Italy. roberta.ferrucci@unimi.it.ORCID http://orcid.org/0000-0001-5109-9483
AOL (United States) · USFondazione Santa Lucia · ITClinique Romande de Réadaptation · CHFukushima Medical University · JPJohns Hopkins University · USNational Hospital for Neurology and Neurosurgery · GBSt George's, University of London · GBThe University of Melbourne · AUUniversity of Milan · ITUniversity of Mons · BEUniversity of Stirling · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cerebellum is involved in multiple closed-loops circuitry which connect the cerebellar modules with the motor cortex, prefrontal, temporal, and parietal cortical areas, and contribute to motor control, cognitive processes, emotional processing, and behavior. Among them, the cerebello-thalamo-cortical pathway represents the anatomical substratum of cerebellum-motor cortex inhibition (CBI). However, the cerebellum is also connected with basal ganglia by disynaptic pathways, and cerebellar involvement in disorders commonly associated with basal ganglia dysfunction (e.g., Parkinson's disease and dystonia) has been suggested. Lately, cerebellar activity has been targeted by non-invasive brain stimulation (NIBS) techniques including transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) to indirectly affect and tune dysfunctional circuitry in the brain. Although the results are promising, several questions remain still unsolved. Here, a panel of experts from different specialties (neurophysiology, neurology, neurosurgery, neuropsychology) reviews the current results on cerebellar NIBS with the aim to derive the future steps and directions needed. We discuss the effects of TMS in the field of cerebellar neurophysiology, the potentials of cerebellar tDCS, the role of animal models in cerebellar NIBS applications, and the possible application of cerebellar NIBS in motor learning, stroke recovery, speech and language functions, neuropsychiatric and movement disorders.

Indexed as

Parkinson DiseaseTranscranial Direct Current StimulationAnimalsCerebellumTranscranial Magnetic StimulationCerebellumNeuromodulationNon-invasivetDCSTMS

Identifiers

PMID34813040
OpenAlexW3215785905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.