Evidence map›Paper›PMID 34812971›Full record

ArticleLasers in medical science2022

Photoinactivation of multispecies cariogenic biofilm mediated by aluminum phthalocyanine chloride encapsulated in chitosan nanoparticles.

Leonardo Lobo Ribeiro Cavalcante, Antonio Claudio Tedesco, Aline Evangelista Souza-Gabriel, Hiago Salge Borges, Fabiana Almeida Curylofo-Zotti, Silmara Aparecida Milori Corona

Abstract read
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In one paragraph

Article in Lasers in medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Leonardo Lobo Ribeiro CavalcanteDepartment of Restorative Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo (USP), Avenida do Café, s/n°, Monte Alegre, Ribeirão Preto, São Paulo, 14040-904, Brazil.
Antonio Claudio TedescoDepartment of Chemistry, Center of Nanotechnology and Tissue Engineers, Photobiology and Photomedicine Research Group, FFCLRP-University of São Paulo (USP), Avenida do Café, s/n°, Monte Alegre, Ribeirão Preto, São Paulo, 14040-904, Brazil.
Aline Evangelista Souza-GabrielDepartment of Restorative Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo (USP), Avenida do Café, s/n°, Monte Alegre, Ribeirão Preto, São Paulo, 14040-904, Brazil.
Hiago Salge BorgesDepartment of Chemistry, Center of Nanotechnology and Tissue Engineers, Photobiology and Photomedicine Research Group, FFCLRP-University of São Paulo (USP), Avenida do Café, s/n°, Monte Alegre, Ribeirão Preto, São Paulo, 14040-904, Brazil.
Fabiana Almeida Curylofo-ZottiDepartment of Restorative Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo (USP), Avenida do Café, s/n°, Monte Alegre, Ribeirão Preto, São Paulo, 14040-904, Brazil.
Silmara Aparecida Milori CoronaDepartment of Restorative Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo (USP), Avenida do Café, s/n°, Monte Alegre, Ribeirão Preto, São Paulo, 14040-904, Brazil. silmaracorona@forp.usp.br.ORCID http://orcid.org/0000-0002-1733-3472
Universidade de São Paulo · BRUniversidade de Ribeirão Preto · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 130399/2021-3Fundação de Amparo à Pesquisa do Estado de São Paulo #2013/50181-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/05965-0
6 · The paper itself

Abstract

This study aimed to characterize the aluminum phthalocyanine chloride (AlClPc) encapsulated in chitosan nanoparticles (CN) and apply it in antimicrobial photodynamic therapy (aPDT) on multispecies biofilm composed of Streptococcus mutans, Lactobacillus casei, and Candida albicans to analyze the antimicrobial activity and lactate production after treatment. Biofilms were formed in 24-well polystyrene plates at 37 °C for 48 h under microaerophilia. The following groups were evaluated (n = 9): as a positive control, 0.12% chlorhexidine gluconate (CHX); phosphate-buffered saline (PBS) as a negative control; 2.5% CN as release vehicle control; the dark toxicity control of the formulations used (AlClPc and AlClPc + CN) was verified in the absence of light; for aPDT, after 30 min incubation time, the photosensitizers at a final concentration of 5.8 × 10

Indexed as

ChitosanNanoparticlesPhotochemotherapyBiofilmsIndolesOrganometallic CompoundsPhotosensitizing AgentsStreptococcus mutansChitosanchloroaluminum phthalocyanineIndolesOrganometallic CompoundsPhotosensitizing AgentsChloro aluminum phthalocyanineMixed biofilmNanocarriersPhotochemotherapy

Identifiers

PMID34812971
OpenAlexW3217287396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.