ArticleClinical oral investigations2022
Involvement of an FTO gene polymorphism in the temporomandibular joint osteoarthritis.
Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Association between fat mass and obesity-related variant and osteoarthritis risk: Integrated meta-analysis with bioinformatics.Frontiers in medicine · 2022Pooled it
- Analysis of Clinical, Biopsychosocial Factors and Mmp3 Polymorphism in Women with TMD.Diagnostics (Basel, Switzerland) · 2026Article
- Association of single nucleotide polymorphisms in FILIP1-SENP6 and FTO with temporomandibular joint osteoarthritis: clinical and in silico study.Scientific reports · 2026Article
- Evaluating the causal effects of life-course adiposity on jaw anomalies.Progress in orthodontics · 2025Article
- Electromyographic evaluation of masseteric activity during maximum opening in patients with temporomandibular disorders and limited mouth opening.Scientific reports · 2025Article
- Therapeutic Potential of FTO Demethylase in Metabolism and Disease Pathways.The protein journal · 2025Review
- Causal association between body mass index and temporomandibular disorders: a bidirectional two-sample Mendelian randomization analysis.BMC oral health · 2023Article
- mActa biochimica et biophysica Sinica · 2023Review
- Smooth muscle cell FTO regulates contractile function.American journal of physiology. Heart and circulatory physiology · 2022Article
- Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe FTO gene has been reported as an obesity-associated gene and is also considered a risk gene for osteoarthritis (OA). However, its exact function is unclear, and there is conflicting evidence on the involvement of FTO polymorphisms in OA via obesity. The purpose of this study was to determine the effects of FTO polymorphism rs8044769 alleles on OA in the temporomandibular joint (TMJ), which is minimally affected by body weight. MATERIALS AND
methodsA total of 324 TMJs (113 with OA and 211 without OA, serving as controls) from 162 Japanese patients with temporomandibular disorders and undergoing MRI examination were analyzed. Genotyping was conducted, and multivariate analysis was performed after adjusting for the effects of age, sex, body mass index, and TMJ disc abnormalities.
resultsMean age, BMI, and sex did not differ between the TMJs with OA and the TMJs without OA, but a significant difference was found for positional and dynamic disc abnormalities (P < 0.05). The allele frequency of FTO polymorphisms also differed significantly between the TMJs with OA and the TMJs without OA (P = 0.011). Moreover, logistic regression analysis showed no significant association between BMI (P = 0.581) and the occurrence of TMJOA but also indicated that the CC allele of rs8044769 is a risk factor for TMJOA (P = 0.040).
conclusionsOur results show that rs8044769 in the FTO gene might be involved in TMJOA. CLINICAL RELEVANCE: The present study provides a basis for a deeper understanding of the mechanism underlying degenerative skeletal diseases and the more effective selection and development of treatment strategies based on the patients' genetic characteristics.
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