Evidence map›Paper›PMID 34812952›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

Exploring the factors influencing adherence to oral anticancer drugs in patients with digestive cancer: a qualitative study.

Pierre Nizet, Yann Touchefeu, Solange Pecout, Estelle Cauchin, Eva Beaudouin, Séverine Mayol, Clémentine Fronteau, Jean-François Huon

Open access · hybridAbstract read
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Patient symptoms, confidence, and adherence during the first 8 weeks of targeted oral anticancer agent treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  7. Evaluation of illness perception and treatment adherence in patients taking oral chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Pierre NizetClinical Pharmacy Unit, Nantes University Hospital, 1 Rue Gaston Veil, 44000, Nantes, France. pierre.nizet@chu-nantes.fr.ORCID http://orcid.org/0000-0001-6912-0025
Yann TouchefeuDigestive Oncology, Institut Des Maladies De L'Appareil Digestif, Nantes University Hospital, Nantes, France.
Solange PecoutDigestive Oncology, Institut Des Maladies De L'Appareil Digestif, Nantes University Hospital, Nantes, France.
Estelle CauchinDigestive Oncology, Institut Des Maladies De L'Appareil Digestif, Nantes University Hospital, Nantes, France.
Eva BeaudouinINSERM, UMR 1246-SPHERE, MethodS in Patients-Centered Outcomes and HEalth ResEarch, Nantes and Tours, France.
Séverine MayolResearch Department, Nantes University Hospital, Nantes, France.
Clémentine FronteauClinical Pharmacy Unit, Nantes University Hospital, 1 Rue Gaston Veil, 44000, Nantes, France.
Jean-François HuonClinical Pharmacy Unit, Nantes University Hospital, 1 Rue Gaston Veil, 44000, Nantes, France.
Inserm · FRNantes Université · FRCentre Hospitalier Universitaire de Nantes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to explore the beliefs, perceptions and representations of patients in order to identify the determinants of oral anticancer drugs adherence and to take action in current practice to improve patient support in digestive oncology.

methodsWe constructed a semi-directed interview guide which aimed to explore the patient's relationship with medication, their health history, their experiences at the time of the announcement of treatment, their confidence, their fears, their motivations to adhere to their treatment and the constraints linked to their treatment. The data were analysed and discussed using a thematic approach.

resultsSeventeen patients agreed to participate in the study. The median age was 60 years. Ten patients had colorectal cancer, 3 patients had hepatocellular carcinoma, 3 patients had gastrointestinal stromal tumour and 1 patient had neuroendocrine pancreatic tumour. We identified five categories of factors influencing adherence: demographic and socioeconomic, disease-related, treatment-related, care system-related, and patient representation and pathways' factors. A majority of patients emphasised the importance of family support in the adherence process and the convenience of per os treatment compared to other intravenous treatments. However, several negative determinants emerged such as the toxicity of the treatment, fears of forgetting to take the medication, difficulties with the galenic formulation and negative beliefs of the family.

conclusionThis study demonstrates the need to address the different dimensions of the patient in order to understand his or her behaviour with regard to adherence and to identify the levers for improvement.

Indexed as

Antineoplastic AgentsNeoplasmsAdministration, OralFemaleHumansMaleMedication AdherenceMiddle AgedQualitative ResearchAntineoplastic AgentsAdherenceOral anticancer drugsPatient experienceQualitative research

Identifiers

PMID34812952
PMCPMC8794904
OpenAlexW3214908723

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.