Evidence map›Paper›PMID 34812607›Full record

ArticleACS chemical neuroscience2021

Novel Positron Emission Tomography Radiotracers for Imaging Mitochondrial Complex I.

Yulong Xu, Yiming Xu, Savannah Biby, Ping Bai, Yan Liu, Can Zhang, Changning Wang, Shijun Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yulong XuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Yiming XuDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Savannah BibyDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Ping BaiAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.ORCID 0000-0003-4587-8426
Yan LiuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Can ZhangDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Charlestown, Massachusetts 02129, United States.ORCID 0000-0002-4340-5118
Changning WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.ORCID 0000-0002-2076-4193
Shijun ZhangDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23298, United States.ORCID 0000-0001-9732-5925
Harvard University · USVirginia Commonwealth University · US

Funding

Development of NLRP3 inflammasome inhibitors towards Alzheimer's diseaseR01AG058673 · NIA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WANG, XIANG-YANG SHAWN, ZHANG, SHIJUN · 2018 to 2020
$2.3M
NIA NIH HHS R01 AG058673
6 · The paper itself

Abstract

Mitochondrial dysfunction has been indicated in neurodegenerative and other disorders. The mitochondrial complex I (MC-I) of the electron transport chain (ETC) on the inner membrane is the electron entry point of the ETC and is essential for the production of reactive oxygen species. Based on a recently identified β-keto-amide type MC-I modulator from our laboratory, an

Indexed as

Positron-Emission TomographyPositron Emission Tomography Computed TomographyBrainElectron Transport Complex IFluorine RadioisotopesRadiopharmaceuticalsElectron Transport Complex IFluorine RadioisotopesRadiopharmaceuticalsAlzheimer’s diseasebrain uptakemitochondrial complex I (MC-I)positron emission tomography (PET)radiotracer

Identifiers

PMID34812607
PMCPMC10071493
OpenAlexW3216903015

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.