Evidence map›Paper›PMID 34812600›Full record

Observational studyJBRA assisted reproduction2022

Correlation between anti-Müllerian hormone, age, and number of oocytes: A retrospective study in a Brazilian in vitro fertilization center.

Isadora Ferreira Kozlowski, Matheus Campos Carneiro, Vinicius Bonato da Rosa, Alessandro Schuffner

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in JBRA assisted reproduction, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Isadora Ferreira KozlowskiFaculdade de Medicina, Pontifícia Universidade Católica Curitiba, Paraná, Brazil.
Matheus Campos CarneiroFaculdade de Medicina, Faculdade Evangélica Mackenzie, Curitiba, Paraná, Brazil.
Vinicius Bonato da RosaConceber Centro de Medicina Reprodutiva, Curitiba, Paraná, Brazil.
Alessandro SchuffnerConceber Centro de Medicina Reprodutiva, Curitiba, Paraná, Brazil.
Instituto Tropical de Medicina Reprodutiva · BRFaculdade Evangélica do Paraná · BRPontifícia Universidade Católica do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIs the AMH level correlated with age and number of mature oocytes retrieved from stimulated cycles?

methodsThis descriptive, retrospective, observational study included the data of about 1500 patients submitted to Assisted Reproductive Technology treatments in a clinic in Brazil between July 2012 and April 2019. Patients not submitted to IVF and/or without AMH level records were excluded. The study included women with fertility issues aged 20-50 years submitted to IVF. A total of 733 patients were included. The patients were divided by age into three groups (≤35 years old; 36-39 years old; ≥40 years old).

resultsThe mean AMH concentration ranged from 2.65 to 1.35 ng/mL and was significantly different between the groups. The mean total number of retrieved oocytes ranged from 9.5 to 5.42 and was significantly different between the groups. The mean number of mature oocytes ranged from 7.14 to 4.58. There was no significant difference in the number of mature oocytes between patients aged 36-39 years and ≥40 years. Negative correlations were observed between patient age and total number of retrieved oocytes (-0.3354) and number of mature oocytes (-0.2839). AMH was negatively correlated with age (-0.3257), although positive correlations with total number of oocytes (0.6702) and number of mature oocytes (0.5770) were observed.

conclusionsThis is the largest study performed with Brazilian patients to correlate AMH levels, age, number of oocytes, and number of mature oocytes from controlled ovarian stimulation cycles. Our data showed that as age increases, AMH levels, number of retrieved oocytes, and number of mature oocytes decrease significantly. However, no significant difference in number of mature oocytes was observed when patients aged 36-39 and ≥40 years were compared. In addition, a positive correlation was found between serum AMH levels and total number of retrieved and mature oocytes from stimulated cycles.

Indexed as

Age FactorsAnti-Mullerian HormoneFertilization in VitroAdultBrazilFemaleHumansMiddle AgedOocytesOvulation InductionRetrospective StudiesYoung AdultAnti-Mullerian HormoneagingAMHassisted reproductive technology

Identifiers

PMID34812600
PMCPMC9118965
OpenAlexW3216594362

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.