Evidence map›Paper›PMID 34812521›Full record

Trial reportCancer2022

Optimization of a technology-supported physical activity promotion intervention for breast cancer survivors: Results from Fit2Thrive.

Siobhan M Phillips, Frank J Penedo, Linda M Collins, Payton Solk, Juned Siddique, Jing Song, David Cella, Kerry S Courneya, Ronald T Ackermann, Whitney A Welch and 5 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06624358 (Physical Activity in Adolescents With Chronic Kidney Disease), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06624358 narecruitingnot on this mapstarted 2025, after this paper: background citation

Physical Activity in Adolescents With Chronic Kidney Disease

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2025 to 2028Enrolled100ConditionsChronic Kidney DiseasesArmsIncrease Physical Activity
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  5. Effects of a Physical Activity mHealth Intervention (Fit2Thrive) on WCRF/AICR Cancer Prevention Recommendations among Breast Cancer Survivors: A Secondary Data Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
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  9. Effect of the Fit2Thrive Intervention on Patient-reported Outcomes in Breast Cancer Survivors: A Randomized Full Factorial Trial.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Siobhan M PhillipsDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0001-8899-3825
Frank J PenedoUniversity of Miami Sylvester Comprehensive Cancer Center, Miami, Florida.
Linda M CollinsNew York University School of Global Public Health, New York, New York.
Payton SolkDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Juned SiddiqueDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Jing SongDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
David CellaDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Kerry S CourneyaFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-9677-3918
Ronald T AckermannDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Whitney A WelchDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Lisa A Auster-GussmanDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Madelyn WhitakerDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0002-6532-1898
Erin CullatherDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Emily IzenmanDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Bonnie SpringDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Northwestern University · USNew York University · USUniversity of Alberta · CAUniversity of Miami · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Research Design, Data, and Analytics CoreP30DK092949 · NIDDK · UNIVERSITY OF CHICAGO · PI MONICA E PEEK · 2011 to 2026
$10.0M
Multi-site adaptive trial of a technology-based, EHR-integrated physical activity intervention in breast and endometrial cancer survivorsR37CA225877 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI PHILLIPS, SIOBHAN MARIE · 2019 to 2025
$4.8M
Cancer Prevention, Control, and Survivorship Research Training ProgramT32CA193193 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Brian L Hitsman, BETINA YANEZ · 2015 to 2026
$3.8M
Designing with Dissemination in Mind: Optimization of a mHealth Physical Activity Intervention for Breast Cancer SurvivorsK07CA196840 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PHILLIPS, SIOBHAN MARIE · 2015 to 2019
$729k
Incorporating Biomarkers of Prognosis and Cardiovascular Disease Risk in the Fit2Thrive Physical Activity Promotion Intervention for Breast Cancer SurvivorsR21CA219028 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PHILLIPS, SIOBHAN MARIE · 2018 to 2019
$400k
NCATS NIH HHS UL1 TR001422NCI NIH HHS K07 CA196840NCI NIH HHS L30 CA199247NCI NIH HHS R21 CA219028NCI NIH HHS R37 CA225877NCI NIH HHS T32 CA193193NIDDK NIH HHS P30 DK092949
6 · The paper itself

Abstract

backgroundThe benefits of moderate to vigorous physical activity (MVPA) for breast cancer survivors are well established. However, most are insufficiently active. Fit2Thrive used the Multiphase Optimization Strategy methodology to determine the effect of 5 intervention components on MVPA in this population.

methodsTwo hundred sixty-nine participants (mean age, 52.5 years; SD, 9.9 years) received a core intervention (the Fit2Thrive self-monitoring app and Fitbit) and were randomly assigned to 5 intervention components set to on/off in a full factorial experiment: support calls, deluxe app, buddy, online gym, and text messages. The intervention was delivered over 12 weeks with a 12-week follow-up. MVPA was measured via accelerometry at the baseline (T1), at 12 weeks (T2), and at 24 weeks (T3). The main effects and interaction effects at each time point were examined for all components.

resultsTrial retention was high: 91.8% had valid accelerometer data at T2 or T3. Across all conditions, there were significant increases in MVPA (+53.6 min/wk; P < .001) and in the proportion of survivors meeting MVPA guidelines (+22.3%; P < .001) at T2 that were maintained but attenuated at T3 (MVPA, +24.6 min/wk; P < .001; meeting guidelines, +12.6%; P < .001). No individual components significantly improved MVPA, although increases were greater for the on level versus the off level for support calls, buddy, and text messages at T2 and T3.

conclusionsThe Fit2Thrive core intervention (the self-monitoring app and Fitbit) is promising for increasing MVPA in breast cancer survivors, but the components provided no additional increases in MVPA. Future research should evaluate the core intervention in a randomized trial and determine what components optimize MVPA behaviors in breast cancer survivors.

Indexed as

Breast NeoplasmsCancer SurvivorsExerciseAccelerometryAdultFemaleHumansMiddle AgedMobile ApplicationsMonitoring, AmbulatorySelf CareTechnologybehavior changebreast cancer survivorsdigital healthinterventionphysical activity

Identifiers

PMID34812521
PMCPMC8837679
OpenAlexW3214833887

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.