Evidence map›Paper›PMID 34812498›Full record

ArticleThe Laryngoscope2022

New Onset of Smell and Taste Loss Are Common Findings Also in Patients With Symptomatic COVID-19 After Complete Vaccination.

Luigi A Vaira, Andrea De Vito, Jerome R Lechien, Carlos M Chiesa-Estomba, Miguel Mayo-Yàñez, Christian Calvo-Henrìquez, Sven Saussez, Giordano Madeddu, Sergio Babudieri, Paolo Boscolo-Rizzo and 2 more

Abstract read
In one paragraph

Article in The Laryngoscope, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. The long-term effect of COVID-19 infection on olfaction and taste; a prospective analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Observational
  4. Article
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  6. Subjective versus Psychophysical Measures of Chemosensory Alterations following COVID-19.ORL; journal for oto-rhino-laryngology and its related specialties · 2024
    Article
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  10. Co-VAN study: COVID-19 vaccine associated neurological diseases- an experience from an apex neurosciences centre and review of the literature.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Luigi A VairaMaxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.ORCID 0000-0002-7789-145X
Andrea De VitoInfectious and Tropical Diseases Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Jerome R LechienCOVID-19 Task Force, Young-Otolaryngologists of the International Federation of Oto-rhino-laryngological Societies, Paris, France.ORCID 0000-0002-0845-0845
Carlos M Chiesa-EstombaCOVID-19 Task Force, Young-Otolaryngologists of the International Federation of Oto-rhino-laryngological Societies, Paris, France.ORCID 0000-0001-9454-9464
Miguel Mayo-YàñezOtorhinolaryngology, Head and Neck Surgery Department, University Hospital Complex of A Coruña, A Coruña, Spain.ORCID 0000-0002-1829-6597
Christian Calvo-HenrìquezOtorhinolaryngology-Head and Neck Surgery Department, Complexo Hospitalario Universitario Santiago de Compostela, Santiago de Compostela, Spain.
Sven SaussezCOVID-19 Task Force, Young-Otolaryngologists of the International Federation of Oto-rhino-laryngological Societies, Paris, France.
Giordano MadedduInfectious and Tropical Diseases Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Sergio BabudieriInfectious and Tropical Diseases Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Paolo Boscolo-RizzoDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Claire HopkinsOtorhinolaryngology Department, King's College, London, U.K.
Giacomo De RiuMaxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to investigate the clinical profile of patients who developed coronavirus disease 2019 (COVID-19) after full vaccination. Demographic, epidemiological and clinical data were collected through medical records and online patient-reported outcome questionnaire from patients who developed symptomatic SARS-CoV-2 infection, confirmed by nasopharyngeal swab, at least 2 weeks after completion of vaccination. A total of 153 subjects were included. The most frequent symptoms were: asthenia (82.4%), chemosensory dysfunction (63.4%), headache (59.5%), runny nose (58.2%), muscle pain (54.9%), loss of appetite (54.3%), and nasal obstruction (51.6%). Particularly, 62.3% and 53.6% of subjects reported olfactory and gustatory dysfunction, respectively. Symptom severity was mild or moderate in almost all cases. Chemosensory dysfunctions have been observed to be a frequent symptom even in subjects who contracted the infection after full vaccination. For this reason, the sudden loss of smell and taste could continue to represent a useful and specific diagnostic marker to raise the suspicion of COVID-19 even in vaccinated subjects. In the future, it will be necessary to establish what the recovery rate is in these patients. LEVEL OF EVIDENCE: 4 Laryngoscope, 132:419-421, 2022.

Indexed as

COVID-19 VaccinesSARS-CoV-2AdultAgeusiaAnosmiaCOVID-19FemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresSmellSurveys and QuestionnairesTasteVaccinationCOVID-19 VaccinesageusiaanosmiaCOVID-19gustatory dysfunctionolfactory dysfunctionvaccination

Identifiers

PMID34812498
PMCPMC9011575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.