Evidence map›Paper›PMID 34812274›Full record

ArticleOxidative medicine and cellular longevity2021

Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2

Ya-Jen Chiu, Te-Hsien Lin, Chiung-Mei Chen, Chih-Hsin Lin, Yu-Shan Teng, Chung-Yin Lin, Ying-Chieh Sun, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Guey-Jen Lee-Chen and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. An overview of structure-based activity outcomes of pyran derivatives against Alzheimer's disease.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Review
  6. Using ΔK280 TauBiomolecules · 2023
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ya-Jen Chiu *Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID https://orcid.org/0000-0003-3195-2509
Te-Hsien Lin *Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID https://orcid.org/0000-0002-1107-772X
Chiung-Mei Chen *Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taoyuan 33302, Taiwan.ORCID https://orcid.org/0000-0002-0769-0353
Chih-Hsin LinDepartment of Neurology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taoyuan 33302, Taiwan.ORCID https://orcid.org/0000-0001-9179-5846
Yu-Shan TengDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID https://orcid.org/0000-0003-0055-4196
Chung-Yin LinMedical Imaging Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Taoyuan 33302, Taiwan.ORCID https://orcid.org/0000-0001-9775-1510
Ying-Chieh SunDepartment of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID https://orcid.org/0000-0003-2615-3606
Hsiu Mei Hsieh-LiDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID https://orcid.org/0000-0001-7435-0714
Ming-Tsan SuDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID https://orcid.org/0000-0003-4758-3728
Guey-Jen Lee-ChenDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID https://orcid.org/0000-0003-4818-9917
Wenwei LinDepartment of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID https://orcid.org/0000-0002-1121-072X
Kuo-Hsuan ChangDepartment of Neurology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taoyuan 33302, Taiwan.ORCID https://orcid.org/0000-0003-4972-9823
National Taiwan Normal University · TWChang Gung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal accumulations of misfolded A

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsChalconesCoumarinsCyclic AMP Response Element-Binding ProteinHumansMaleMiceMice, Inbred ICRNeuroblastomaNeuroprotective Agentstau ProteinsAmyloid beta-PeptidesChalconesCoumarinsCyclic AMP Response Element-Binding ProteinMapt protein, mouseNeuroprotective Agentstau Proteins

Identifiers

PMID34812274
PMCPMC8605905
OpenAlexW3212754548

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.