Evidence map›Paper›PMID 34812142›Full record

ArticleeLife2021

Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A.

Blake A Creighton, Simone Afriyie, Deepa Ajit, Cristine R Casingal, Kayleigh M Voos, Joan Reger, April M Burch, Eric Dyne, Julia Bay, Jeffrey K Huang and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Longitudinal Characterization of GiantResearch (Washington, D.C.) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Reappraisal ofReviews in cardiovascular medicine · 2025
    Review
  8. Review
  9. Putting the brakes on axonal branching.Trends in neurosciences · 2024
    Article
  10. Article
  11. Article
  12. Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Blake A Creighton *Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Simone Afriyie *Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Deepa AjitDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0002-6062-7070
Cristine R CasingalDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Kayleigh M VoosDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Joan RegerNational Institute of Neurological Disorders and Stroke (NINDS), Bethesda, United States.
April M BurchDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Eric DyneNational Institute of Neurological Disorders and Stroke (NINDS), Bethesda, United States.
Julia BayDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Jeffrey K HuangDepartment of Biology and Center for Cell Reprogramming, Georgetown University, Washington, United States.
E S AntonDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Meng-Meng FuNational Institute of Neurological Disorders and Stroke (NINDS), Bethesda, United States.
Damaris N LorenzoDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0002-6856-2988
University of North Carolina at Chapel Hill · USGeorgetown University · USNational Institute of Neurological Disorders and Stroke · US

Funding

UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Preclinical CoreU54HD079124 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YUN · 2013 to 2019
$8.0M
DEFINING MECHANISMS OF PROGENITOR BALANCE AND NEURONAL CONNECTIVITYR35NS116859 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVA S ANTON · 2020 to 2026
$4.1M
Role of Radial Glial Tiling in the Formation and Malformation of the Cerebral CortexR01HD098657 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON, EVA S · 2019 to 2023
$2.5M
Role of Ankyrin-B in the Nervous SystemR01NS110810 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LORENZO, DAMARIS N · 2020 to 2024
$1.9M
NICHD NIH HHS P50 HD103573NICHD NIH HHS R01 HD098657NICHD NIH HHS U54 HD079124NINDS NIH HHS P30 NS045892NINDS NIH HHS R01 NS110810NINDS NIH HHS R35 NS116859
6 · The paper itself

Abstract

Variants in the high confident autism spectrum disorder (ASD) gene

Indexed as

AnimalsAnkyrinsAxon GuidanceAxonsMiceSemaphorin-3ASignal TransductionAnk2 protein, mouseAnkyrinsSema3a protein, mouseSemaphorin-3AANK2ankyrinautismaxon branchingcell biologygrowth conemouseneuroscienceSema 3a

Identifiers

PMID34812142
PMCPMC8610419
OpenAlexW3215848947

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.