Evidence map›Paper›PMID 34812139›Full record

ArticleeLife2021

BRAF

Andrew S McNeal, Rachel L Belote, Hanlin Zeng, Marcus Urquijo, Kendra Barker, Rodrigo Torres, Meghan Curtin, A Hunter Shain, Robert Hi Andtbacka, Sheri Holmen and 7 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Ancestry and somatic profile predict acral melanoma origin and prognosis.medRxiv : the preprint server for health sciences · 2025
    Article
  10. Crosstalk in Skin: Loss of Desmoglein 1 in Keratinocytes Inhibits BRAFThe Journal of investigative dermatology · 2025
    Article
  11. Article
  12. Article
  13. Transdermal delivery of ultradeformable cationic liposomes complexed with miR211-5p (UCL-211) stabilizes BRAFV600E+ melanocytic nevi.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  14. Cancer research and the mainstream of biology.Frontiers in cell and developmental biology · 2025
    Review
  15. Aardvark: Composite Visualizations of Trees, Time-Series, and Images.IEEE transactions on visualization and computer graphics · 2025
    Article
  16. Identification of Oncogene-Induced Senescence-Associated MicroRNAs.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  17. Dangerous liaisons: Loss of keratinocyte control over melanocytes in melanomagenesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Andrew S McNealUniversity of California, San Francisco, San Francisco, United States.
Rachel L BeloteHuntsman Cancer Inst., Salt Lake City, United States.
Hanlin ZengHuntsman Cancer Inst., Salt Lake City, United States.
Marcus UrquijoHuntsman Cancer Inst., Salt Lake City, United States.
Kendra BarkerHuntsman Cancer Inst., Salt Lake City, United States.
Rodrigo TorresUniversity of California, San Francisco, San Francisco, United States.
Meghan CurtinHuntsman Cancer Inst., Salt Lake City, United States.
A Hunter ShainUniversity of California, San Francisco, San Francisco, United States.
Robert Hi AndtbackaHuntsman Cancer Inst., Salt Lake City, United States.
Sheri HolmenHuntsman Cancer Inst., Salt Lake City, United States.
David H LumHuntsman Cancer Inst., Salt Lake City, United States.
Timothy H McCalmontUniversity of California, San Francisco, San Francisco, United States.
Matt W VanBrocklinHuntsman Cancer Inst., Salt Lake City, United States.
Douglas GrossmanHuntsman Cancer Inst., Salt Lake City, United States.
Maria L WeiUniversity of California, San Francisco, San Francisco, United States.
Ursula E LangUniversity of California, San Francisco, San Francisco, United States.
Robert L Judson-TorresHuntsman Cancer Inst., Salt Lake City, United States.ORCID https://orcid.org/0000-0002-6559-0553
Huntsman (United States) · USUniversity of California, San Francisco · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
MicroRNA-Based Detection of Barriers to Melanoma ProgressionDP5OD019787 · OD · UNIVERSITY OF UTAH · PI JUDSON-TORRES, ROBERT LAIRD · 2014 to 2018
$1.9M
Nevus associated microRNAs as mediators of BRAF-induced growth arrest and biomarkers of melanoma progressionR01CA229896 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI JUDSON-TORRES, ROBERT LAIRD · 2021 to 2025
$1.8M
Defining the role of SWI/SNF chromatin remodeling complex mutations during melanoma progressionK22CA217997 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHAIN, ALAN HUNTER · 2018 to 2021
$651k
Ovarian Cancer Biomarker Discovery using scFv ArraysF31CA123637 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI RAMIREZ, ARTURO B · 2006 to 2009
$130k
NCI NIH HHS F31 CA123637NCI NIH HHS K22 CA217997NCI NIH HHS P30 CA042014NCI NIH HHS R01 CA229896NIH HHS DP5 OD019787
6 · The paper itself

Abstract

Benign melanocytic nevi frequently emerge when an acquired

Indexed as

Aurora Kinase BHumansMelanocytesMicroRNAsMitosisProto-Oncogene Proteins B-rafSignal TransductionAURKB protein, humanAurora Kinase BBRAF protein, humanMicroRNAsProto-Oncogene Proteins B-rafcancer biologygeneticsgenomicshumanmelanocytesmelanomamicroRNAnevi

Identifiers

PMID34812139
PMCPMC8610417
OpenAlexW3216562252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.