Evidence map›Paper›PMID 34812124›Full record

ArticlemAbs

Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX.

Joey G Sheff, John F Kelly, Anna Robotham, Traian Sulea, Félix Malenfant, Denis L'Abbé, Mélanie Duchesne, Alex Pelletier, Jean Lefebvre, Andrea Acel and 11 more

Open access · goldAbstract read
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Immunoproteomics: The Evolution from Classical Methods to Emerging Techniques.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Joey G SheffHuman Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.ORCID 0000-0002-9269-6863
John F KellyHuman Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.
Anna RobothamHuman Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.
Traian SuleaHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.ORCID 0000-0001-5301-8261
Félix MalenfantHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.
Denis L'AbbéHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.
Mélanie DuchesneHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.
Alex PelletierHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.
Jean LefebvreHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.
Andrea AcelHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.
Marie ParatHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.ORCID 0000-0003-4835-4345
Mylene GosselinHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.
Cunle WuHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.
Yves FortinHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.
Jason BaardsnesHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.ORCID 0000-0001-5587-3034
Henk Van FaassenHuman Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.
Shannon AwreyDepartment of Integrative Oncology, Bc Cancer Research Institute, Vancouver, BC, Canada.ORCID 0000-0001-9905-6853
Shawn C ChafeDepartment of Integrative Oncology, Bc Cancer Research Institute, Vancouver, BC, Canada.ORCID 0000-0001-8802-651X
Paul C McDonaldDepartment of Integrative Oncology, Bc Cancer Research Institute, Vancouver, BC, Canada.ORCID 0000-0002-7238-2912
Shoukat DedharDepartment of Integrative Oncology, Bc Cancer Research Institute, Vancouver, BC, Canada.ORCID 0000-0003-4355-1657
Anne E G LenferinkHuman Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada.ORCID 0000-0001-9825-281X
National Research Council Canada · CAUniversity of British Columbia · CA

Funding

CIHR FDN-143318
6 · The paper itself

Abstract

Human carbonic anhydrase (hCAIX), an extracellular enzyme that catalyzes the reversible hydration of CO

Indexed as

Deuterium Exchange MeasurementHydrogen Deuterium Exchange-Mass SpectrometryAntibodies, MonoclonalCatalytic DomainDeuteriumEpitope MappingHumansAntibodies, MonoclonalDeuteriumallosteryantibodyantibody-drug conjugateanti-cancer targetCarbonic anhydraseepitope mappinghydrogen-deuterium exchangemass spectrometrytumor microenvironment

Identifiers

PMID34812124
PMCPMC8632303
OpenAlexW3215962778

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.