Evidence map›Paper›PMID 34812056›Full record

ArticleASN neuro

Effects of Manipulation of Noradrenergic Activities on the Expression of Dopaminergic Phenotypes in Aged Rat Brains.

Fei Zeng, Yan Fan, Russell W Brown, Wesley Drew Gill, Jennifer B Price, Thomas C Jones, Meng-Yang Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ASN neuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Neuroprotective actions of norepinephrine in neurological diseases.Pflugers Archiv : European journal of physiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Fei ZengDepartment of Neurology, Renmin Hospital of the Wuhan University, China.
Yan FanDepartments of Biomedical Sciences, Quillen College of Medicine, 4154East Tennessee State University, USA.
Russell W BrownDepartments of Biomedical Sciences, Quillen College of Medicine, 4154East Tennessee State University, USA.
Wesley Drew GillDepartments of Biomedical Sciences, Quillen College of Medicine, 4154East Tennessee State University, USA.
Jennifer B PriceDepartment of Biological Sciences, College of Arts and Sciences, 4154East Tennessee State University, USA.
Thomas C JonesDepartment of Biological Sciences, College of Arts and Sciences, 4154East Tennessee State University, USA.
Meng-Yang ZhuDepartments of Biomedical Sciences, Quillen College of Medicine, 4154East Tennessee State University, USA.ORCID 0000-0002-5403-1270
East Tennessee State University · USFlorida State University · US

Funding

Restoration of noradrenergic and dopaminergic functions in the brain of aged rats.R15AG055107 · NIA · EAST TENNESSEE STATE UNIVERSITY · PI ZHU, MENG-YANG · 2018 to 2018
$444k
NIA NIH HHS R15 AG055107
6 · The paper itself

Abstract

This study investigated the effects of the pharmacological manipulation of noradrenergic activities on dopaminergic phenotypes in aged rats. Results showed that the administration of L-threo-3,4-dihydroxyphenylserine (L-DOPS) for 21 days significantly increased the expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT) in the striatum and substantia nigra (SN) of 23-month-old rats. Furthermore, this treatment significantly increased norepinephrine/DA concentrations in the striatum and caused a deficit of sensorimotor gating as measured by prepulse inhibition (PPI). Next, old rats were injected with the α2-adrenoceptor antagonist 2-methoxy idazoxan or β2-adrenoceptor agonist salmeterol for 21 days. Both drugs produced similar changes of TH and DAT in the striatum and SN. Moreover, treatments with L-DOPS, 2-methoxy idazoxan, or salmeterol significantly increased the protein levels of phosphorylated Akt in rat striatum and SN. However, although a combination of 2-methoxy idazoxan and salmeterol resulted in a deficit of PPI in these rats, the administration of 2-methoxy idazoxan alone showed an opposite behavioral change. The

Indexed as

DopamineNorepinephrineAnimalsHistone DeacetylasesPhenotypeRatsSubstantia NigraTyrosine 3-MonooxygenaseDopamineHdac5 protein, ratHistone DeacetylasesNorepinephrineTyrosine 3-Monooxygenaseadrenal receptorsL-DOPSnorepinephrineprepulse inhibitionTyrosine hydroxylase dopamine transporter

Identifiers

PMID34812056
PMCPMC8613899
OpenAlexW3217763556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.