Evidence map›Paper›PMID 34811959›Full record

ArticleESC heart failure2022

Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure -A clinical practice Guideline Level 3.

Alexander Assmann, Andreas Beckmann, Christof Schmid, Karl Werdan, Guido Michels, Oliver Miera, Florian Schmidt, Stefan Klotz, Christoph Starck, Kevin Pilarczyk and 34 more

Abstract read
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.Interdisciplinary cardiovascular and thoracic surgery · 2025
    Article
  11. 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025
    Article
  12. Article
  13. Article
  14. Article
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  16. Article
  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Alexander AssmannDepartment of Cardiac Surgery, Heinrich Heine University, Medical Faculty, Moorenstr. 5, Düsseldorf, 40225, Germany.ORCID 0000-0003-3777-7772
Andreas BeckmannGerman Society for Thoracic and Cardiovascular Surgery, Langenbeck-Virchow-Haus, Berlin, Germany.
Christof SchmidDepartment of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.
Karl WerdanClinic for Internal Medicine III, University Hospital Halle (Saale), Martin-Luther University Halle-Wittenberg, Halle, Germany.
Guido MichelsDepartment of Acute and Emergency Care, St Antonius Hospital Eschweiler, Eschweiler, Germany.
Oliver MieraDepartment of Congenital Heart Disease-Pediatric Cardiology, German Heart Center Berlin, Berlin, Germany.
Florian SchmidtDepartment of Pediatric Cardiology and Intensive Care Medicine, Medical School Hannover, Hannover, Germany.
Stefan KlotzDepartment of Cardiac Surgery, Segeberger Kliniken, Bad Segeberg, Germany.
Christoph StarckDepartment of Cardiothoracic and Vascular Surgery, German Heart Centre, Berlin, Germany.
Kevin PilarczykDepartment for Intensive Care Medicine, Imland Hospital Rendsburg, Rendsburg, Schleswig-Holstein, Germany.
Ardawan RastanDepartment of Cardiac and Vascular Thoracic Surgery, Philipps-University Hospital Marburg, Marburg, Germany.
Marion BurckhardtDepartment of Health Sciences and Management, Baden-Wuerttemberg Cooperative State University (DHBW), Stuttgart, Germany.
Monika NothackerInstitute for Medical Knowledge Management, Association of the Scientific Medical Societies (AWMF), Universität Marburg, Marburg, Germany.
Ralf MuellenbachDepartment of Anaesthesiology and Critical Care Medicine, Campus Kassel of the University of Southampton, Kassel, Germany.
York ZausigDepartment of Anesthesiology and Operative Intensive Care Medicine, Aschaffenburg-Alzenau Hospital, Aschaffenburg, Bavaria, Germany.
Nils HaakeDepartment for Intensive Care Medicine, Imland Hospital Rendsburg, Rendsburg, Schleswig-Holstein, Germany.
Heinrich GroesdonkDepartment of Intensive Care Medicine, Helios Clinic Erfurt, Erfurt, Germany.
Markus FerrariHSK, Clinic of Internal Medicine I, Helios-Kliniken, Wiesbaden, Germany.
Michael BuerkeDepartment of Cardiology, Angiology and Internal Intensive Care Medicine, St. Marienkrankenhaus Siegen, Siegen, Germany.
Marcus HennersdorfDepartment of Cardiology, Pneumology, Angiology and Internal Intensive Care Medicine, SLK-Kliniken Heilbronn, Heilbronn, Germany.
Mark RosenbergKlinikum Aschaffenburg-Alzenau, Medizinische Klinik 1, Aschaffenburg, Germany.
Thomas SchaibleDepartment of Neonatology, University Children's Hospital Mannheim, University of Heidelberg, Mannheim, Germany.
Harald KöditzMedical University Children's Hospital, Hannover, Germany.
Stefan KlugeKlinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Uwe JanssensMedical Clinic and Medical Intensive Care Medicine, St Antonius Hospital, Eschweiler, Germany.
Matthias LubnowDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Andreas FlemmerDivision of Neonatology, Dr. v. Hauner Children's Hospital and Perinatal Center Munich - Grosshadern, LMU Munich, Munich, Germany.
Susanne Herber-JonatDivision of Neonatology, Dr. v. Hauner Children's Hospital and Perinatal Center Munich - Grosshader, LMU Munich, Munich, Germany.
Lucas WesselDepartment of Pediatric Surgery, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
Dirk BuchwaldDepartment of Cardiothoracic Surgery, University Hospital Bergmannsheil, Ruhr-University, Bochum, Germany.
Sven MaierDepartment of Cardiovascular Surgery, Heart Center Freiburg University, Freiburg, Germany.
Lars KrügerDivision of Thoracic and Cardiovascular Surgery, Heart- and Diabetescentre NRW, Ruhr-University, Bochum, Germany.
Andreas FründDepartment of Physiotherapy, Heart- and Diabetescentre NRW, Ruhr-University, Bochum, Germany.
Rolf JakstiesGerman Heart Foundation, Germany.
Stefan FischerDepartment of Thoracic Surgery and Lung Support, Ibbenbueren General Hospital, Ibbenbueren, Germany.
Karsten WiebeDepartment of Cardiothoracic Surgery, Münster University Hospital, Münster, Germany.
Christiane S HartogDepartment of Anesthesiology and Operative Intensive Care Medicine, Charité Universitätsmedizin Berlin, and Klinik Bavaria, Kreischa, Germany.
Omer DzemaliDepartment of Cardiac Surgery, Triemli City Hospital Zurich, Zurich, Switzerland.
Daniel ZimpferDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Elfriede Ruttmann-UlmerDepartment of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Christian SchlensakDepartment of Cardio-Thoracic and Vascular Surgery, University of Tübingen, Tübingen, Germany.
Malte KelmDepartment of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.
Stephan EnsmingerDepartment of Cardiac and Thoracic Vascular Surgery, University Hospital of Schleswig-Holstein, Lübeck, Germany.
Udo BoekenDepartment of Cardiac Surgery, Heinrich Heine University, Medical Faculty, Moorenstr. 5, Düsseldorf, 40225, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims Worldwide applications of extracorporeal circulation for mechanical support in cardiac and circulatory failure, which are referred to as extracorporeal life support (ECLS) or veno-arterial extracorporeal membrane oxygenation (va-ECMO), have dramatically increased over the past decade. In spite of the expanding use and the immense medical as well as socio-economic impact of this therapeutic approach, there has been a lack of interdisciplinary recommendations considering the best available evidence for ECLS treatment. Methods and Results In a multiprofessional, interdisciplinary scientific effort of all scientific societies involved in the treatment of patients with acute cardiac and circulatory failure, the first evidence- and expert consensus-based guideline (level S3) on ECLS/ECMO therapy was developed in a structured approach under regulations of the AWMF (Association of the Scientific Medical Societies in Germany) and under use of GRADE (Grading of Recommendations Assessment, Development and Evaluation) criteria. This article presents all recommendations created by the expert panel, addressing a multitude of aspects for ECLS initiation, continuation, weaning and aftercare as well as structural and personnel requirements. Conclusions This first evidence- and expert consensus-based guideline (level S3) on ECLS/ECMO therapy should be used to apply the best available care nationwide. Beyond clinical practice advice, remaining important research aspects for future scientific efforts are formulated.

Indexed as

Extracorporeal Membrane OxygenationShockExtracorporeal CirculationGermanyHumansPractice Guidelines as TopicCardiac and circulatory failureExtracorporeal life support (ECLS)Extracorporeal membrane oxygenation (ECMO)GuidelineRecommendation

Identifiers

PMID34811959
PMCPMC8788014

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.