Evidence map›Paper›PMID 34811949›Full record

ArticleHepatology communications2022

Dysmetabolism, Diabetes and Clinical Outcomes in Patients Cured of Chronic Hepatitis C: A Real-Life Cohort Study.

Luca Valenti, Serena Pelusi, Alessio Aghemo, Sara Gritti, Luisa Pasulo, Cristiana Bianco, Claudia Iegri, Giuliana Cologni, Elisabetta Degasperi, Roberta D'Ambrosio and 31 more

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Cumulative Metformin Use and Hepatocellular Carcinoma Risk After HCV SVR: A Multicentre Cohort Study.Liver international : official journal of the International Association for the Study of the Liver · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 3 countries.

Luca ValentiDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy.ORCID 0000-0001-8909-0345
Serena PelusiDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy.
Alessio AghemoDepartment of Internal Medicine and Hepatology, Humanitas University and Research Hospital, Rozzano, Italy.
Sara GrittiFondazione Ricerca Ospedale di Bergamo, Papa Giovanni Hospital, Bergamo, Italy.
Luisa PasuloDepartment of Gastroenterology and Hepatology, Papa Giovanni Hospital, Bergamo, Italy.
Cristiana BiancoPrecision Medicine Lab, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milano, Italy.ORCID 0000-0003-4611-6781
Claudia IegriDepartment of Gastroenterology and Hepatology, Papa Giovanni Hospital, Bergamo, Italy.
Giuliana CologniDepartment of Internal Medicine, Papa Giovanni Hospital, Bergamo, Italy.
Elisabetta DegasperiDivision of Gastroenterology & Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milano, Italy.ORCID 0000-0002-9899-4669
Roberta D'AmbrosioDivision of Gastroenterology & Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milano, Italy.
Paolo Del PoggioDepartment of Gastroenterology and Hepatology, Papa Giovanni Hospital, Bergamo, Zingonia, Italy.
Alessandro SoriaDivision of Infectious Diseases, San Gerardo Hospital-ASST Monza, Monza, Italy.
Massimo PuotiDepartment of Infectious Diseases, Hepatitis Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Isabella CarderiASST Bergamo Est Bergamo HCV Network, Bergamo, Italy.
Marie Graciella PigozziDepartment of Gastroenterology, Spedali Civili Hospital, Brescia, Italy.
Canio CarrieroDepartment of Infectious Diseases, Spedali Civili Hospital-ASST Brescia, Brescia, Italy.ORCID 0000-0002-2815-0508
Angiola SpinettiDepartment of Infectious Diseases, Spedali Civili Hospital-ASST Brescia, Brescia, Italy.
Valentina ZuccaroDepartment of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo di Pavia, Pavia, Italy.
Massimo MemoliLiver Center, San Raffaele Scientific Institute IRCCS, Milano, Italy.
Alessia GiorginiDepartment of Gastroenterology and Hepatology, San Paolo Hospital, ASST Santi Paolo e Carlo, Milan, Italy.
Mauro ViganòDepartment of Gastroenterology and Hepatology, San Giuseppe Hospital, Milan, Italy.
Maria Grazia RumiDepartment of Gastroenterology and Hepatology, San Giuseppe Hospital, Milan, Italy.
Tiziana ReDepartment of Gastroenterology and Hepatology, Legnano Hospital-ASST Milano Ovest, Milan, Italy.
Ombretta SpinelliDepartment of Gastroenterology and Hepatology, Lariana Como Hospital, Milan, Italy.
Maria Chiara ColomboDepartment of Gastroenterology and Hepatology, Lariana Como Hospital, Milan, Italy.
Tiziana QuirinoDepartment of Gastroenterology and Hepatology, Busto Arsizio Hospital ASST Valle Olona, Milan, Italy.
Barbara MenzaghiDepartment of Gastroenterology and Hepatology, Busto Arsizio Hospital ASST Valle Olona, Milan, Italy.
Gianpaolo LoriniDepartment of Gastroenterology and Hepatology, ASST Franciacorta, Milan, Italy.
Angelo PanDepartment of Internal Medicine, Ospedale di Cremona, Cremona, Italy.
Antonella D'Arminio MonforteDepartment of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Milan, Italy.
Elisabetta BuscariniDepartment of Gastroenterology, Ospedale Maggiore, Crema, Italy.
Aldo AutolitanoASST Pavia Mortara, Mortara, Italy.
Paolo BonfantiDivision of Infectious Diseases, ASST Lecco, Lecco, Italy.
Natalia TerreniOspedale Como - Valduce, Como, Italy.
Gianpiero AimoASST Garda, Desenzano-Manerbio, Italy.
Monia MendeniASST Valcamonica, Esine, Italy.
Daniele PratiPrecision Medicine Lab, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milano, Italy.ORCID 0000-0002-2281-7498
Pietro LamperticoDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy.ORCID 0000-0002-1026-7476
Massimo ColomboLiver Center, San Raffaele Scientific Institute IRCCS, Milano, Italy.
Stefano FagiuoliDepartment of Gastroenterology and Hepatology, Papa Giovanni Hospital, Bergamo, Italy.
NAVIGATORE-Lombardia Network
Ospedale Papa Giovanni XXIII · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Milan · ITVita-Salute San Raffaele University · ITAOL (United States) · USOspedale di Circolo di Busto Arsizio · ITOspedale San Giuseppe · ITAlessandro Manzoni Hospital · ITATS Sardegna (Italy) · ITAzienda Ospedaliera Ospedale Maggiore · ITAzienda Ospedaliera San Gerardo · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITAzienda Socio Sanitaria Territoriale Lariana · ITCasa di Cura Villa Garda · ITCentro Studi GISED · ITHumanitas University · ITIstituti Ospitalieri di Cremona · ITOspedale Valduce · ITPoliclinico San Matteo Fondazione · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to examine the impact of features of dysmetabolism on liver disease severity, evolution, and clinical outcomes in a real-life cohort of patients treated with direct acting antivirals for chronic hepatitis C virus (HCV) infection. To this end, we considered 7,007 patients treated between 2014 and 2018, 65.3% with advanced fibrosis, of whom 97.7% achieved viral eradication (NAVIGATORE-Lombardia registry). In a subset (n = 748), liver stiffness measurement (LSM) was available at baseline and follow-up. Higher body mass index (BMI; odds ratio [OR] 1.06 per kg/m

Indexed as

Carcinoma, HepatocellularCardiovascular DiseasesDiabetes MellitusHepatitis C, ChronicLiver NeoplasmsAntiviral AgentsCohort StudiesHumansLiver CirrhosisSustained Virologic ResponseAntiviral Agents

Identifiers

PMID34811949
PMCPMC8948549
OpenAlexW3215236688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.