ArticleCommunications biology2021
Incrimination of shrews as a reservoir for Powassan virus.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Diversity and transmission and zoonotic potential of microbes in true insectivores.Nature communications · 2025Pooled it
- Powassan Virus in the United States: An AI-Integrative One Health Scoping Review of Ecological Drivers, Zoonotic Interactions, Symptom Profiles, and Public Health Implications.Infectious disease reports · 2026Review
- Arboviral infections of the central nervous system: Mechanisms of invasion and long-term consequences.Journal of neurovirology · 2026Review
- Insectivores exhibit superior microbial network connectivity and elevated zoonotic risk by 2035 relative to rodents and bats.Science China. Life sciences · 2026Article
- A global-scale assessment of zoonotic virus diversity and spillover potential in urban-adapted mammal species.Nature microbiology · 2026Article
- Deer tick virus genotypes are perpetuated by different modes of transmission.bioRxiv : the preprint server for biology · 2026Article
- Epidemiology and risk analysis of Powassan virus infection, New York state, USA, 2013-2023.Epidemiology and infection · 2026Article
- Detection of Tick-Borne Microorganisms, Anaplasmataceae and Piroplasmida, inMicroorganisms · 2025Article
- Atomic-resolution structure of a chimeric Powassan tick-borne flavivirus.Science advances · 2025Article
- Differential Virulence and Host-Specific Fitness of Regionally Distinct Human-Derived Powassan Virus Lineage 2 Strains.The American journal of tropical medicine and hygiene · 2025Article
- Future threats: Animal orthoflaviviruses that currently infect fewer than 100 people per year.Cell reports · 2025Review
- Henipavirus in Northern Short-Tailed Shrew, Alabama, USA.Emerging infectious diseases · 2025Article
- Minor Hosts Have a Major Impact on the Enzootic Transmission of Borrelia burgdorferi.The American journal of tropical medicine and hygiene · 2025Article
- The structure of the proteins of Camp Hill virus.PloS one · 2025Article
- Features of Consistent Powassan Virus Lineage II Focus in Southern Maine, United States.The American journal of tropical medicine and hygiene · 2024Article
- Prevalence and Genetic Diversity of Deer Tick Virus (Powassan Virus, Lineage II) in Ixodes scapularis Ticks in Five Habitats at a Nature Reserve in Southern Maine, United States.The American journal of tropical medicine and hygiene · 2024Article
- Host-pathogen associations inferred from bloodmeal analyses ofApplied and environmental microbiology · 2024Article
- Viruses Identified in Shrews (Viruses · 2024Review
- Interspecies co-feeding transmission of Powassan virus between a native tick, Ixodes scapularis, and the invasive East Asian tick, Haemaphysalis longicornis.Parasites & vectors · 2024Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Powassan virus lineage 2 (deer tick virus) is an emergent threat to American public health, causing severe neurologic disease. Its life cycle in nature remains poorly understood. We use a host-specific retrotransposon-targeted real time PCR assay to test the hypothesis that white-footed mice, considered the main eastern U.S. reservoir of the coinfecting agent of Lyme disease, is the reservoir for deer tick virus. Of 20 virus-infected host-seeking nymphal black-legged ticks 65% fed on shrews and none on mice. The proportion of ticks feeding on shrews at a site is positively associated with prevalence of viral infection, but not the Lyme disease agent. Viral RNA is detected in the brain of one shrew. We conclude that shrews are a likely reservoir host for deer tick virus and that host bloodmeal analysis can provide direct evidence to incriminate reservoir hosts, thereby promoting our understanding of the ecology of tick-borne infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.