Evidence map›Paper›PMID 34811478›Full record

ArticleNature chemistry2021

A dual cellular-heterogeneous catalyst strategy for the production of olefins from glucose.

Zhen Q Wang, Heng Song, Edward J Koleski, Noritaka Hara, Dae Sung Park, Gaurav Kumar, Yejin Min, Paul J Dauenhauer, Michelle C Y Chang

Abstract read
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In one paragraph

Article in Nature chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Intrinsic Ability of the β-Oxidation Pathway To Produce Bioactive Styrylpyrones.Angewandte Chemie (International ed. in English) · 2022
    Article
  8. Reverse β-oxidation pathways for efficient chemical production.Journal of industrial microbiology & biotechnology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Zhen Q Wang *Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA. zhenw@buffalo.edu.ORCID http://orcid.org/0000-0002-3244-690X
Heng Song *Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-0049-5053
Edward J KoleskiDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Noritaka HaraDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Dae Sung ParkDepartment of Chemical Engineering & Materials Science, University of Minnesota, Minneapolis, MN, USA.
Gaurav KumarDepartment of Chemical Engineering & Materials Science, University of Minnesota, Minneapolis, MN, USA.
Yejin MinDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Paul J DauenhauerDepartment of Chemical Engineering & Materials Science, University of Minnesota, Minneapolis, MN, USA.
Michelle C Y ChangDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA. mcchang@berkeley.edu.ORCID http://orcid.org/0000-0003-3747-7630

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Living systems provide a promising approach to chemical synthesis, having been optimized by evolution to convert renewable carbon sources, such as glucose, into an enormous range of small molecules. However, a large number of synthetic structures can still be difficult to obtain solely from cells, such as unsubstituted hydrocarbons. In this work, we demonstrate the use of a dual cellular-heterogeneous catalytic strategy to produce olefins from glucose using a selective hydrolase to generate an activated intermediate that is readily deoxygenated. Using a new family of iterative thiolase enzymes, we genetically engineered a microbial strain that produces 4.3 ± 0.4 g l

Indexed as

Acetyl-CoA C-AcyltransferaseAlkenesBacteriaBacterial ProteinsCatalysisDecarboxylationEnoyl-CoA HydrataseFatty Acid DesaturasesFatty AcidsGlucoseLewis AcidsOxidation-ReductionPalmitoyl-CoA HydrolaseAcetyl-CoA C-AcyltransferaseAlkenesBacterial ProteinsEnoyl-CoA HydrataseFatty Acid DesaturasesFatty AcidsGlucoseLewis AcidsPalmitoyl-CoA Hydrolase

Identifiers

PMID34811478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.