ArticleScientific reports2021
A metabolomics approach to evaluate the effect of lyophilization versus oven drying on the chemical composition of plant extracts.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 48 citations in OpenAlex.
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- Induction of Bioactive Secondary Metabolites inPlant-environment interactions (Hoboken, N.J.) · 2025Article
- Stress-Induced Secondary Metabolite Profiling inInternational journal of molecular sciences · 2025Article
- Metabolomic profiles of the silage digested in ruminal fermentation differentiated by various solvent extraction.Journal of advanced veterinary and animal research · 2025Article
- Variation in terpenoids and antioxidant activity of loquat flowers during post-harvest processing: a metabolomics study.Frontiers in plant science · 2025Article
- Optimizing processing methods for maximum bioactive retention: comparative metabolomic analysis of dried loquat (Frontiers in nutrition · 2025Article
- Extraction efficiency and bioactive evaluation of Tamarix nilotica and Arthrocnemum macrostachyum extracts for anti-cancer potential.PloS one · 2025Article
- Metabolic profiling and antibacterial activity of tree wood extracts obtained under variable extraction conditions.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Multitarget Phytocomplex: Focus on Antibacterial Profiles of Grape Pomace andAntibiotics (Basel, Switzerland) · 2024Article
- Non-Targeted Nuclear Magnetic Resonance Analysis for Food Authenticity: A Comparative Study on Tomato Samples.Molecules (Basel, Switzerland) · 2024Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Lyophilization is the "gold standard" for drying plant extracts, which is important in preserving their quality and extending their shelf-life. Compared to other methods of drying plant extracts, lyophilization is costlier due to equipment, material and operational expenses. An alternative method is post-extraction oven-drying, but the effects of this process on extract quality are unknown. In this study, crude extracts from Arthrocnemum macrostachyum shoots were compared using three post-extraction drying methods (lyophilization and oven drying at 40 and 60 °C) and two extraction solvents (water and aqueous 50% ethanol). Untargeted metabolomics coupled with chemometrics analysis revealed that post extraction oven-drying resulted in the loss of up to 27% of molecular features when compared to lyophilization in water extracts only. In contrast, only 3% of molecular features were lost in aqueous 50% ethanol extracts when subjected to oven drying. That is to say, ethanol used as a solvent has a stabilizing effect on metabolites and enhances their resistance to thermal transformation in the oven. Collectively, oven-drying of extracts was as effective as lyophilization in preserving metabolites in extracts only when 50% ethanol was used as a solvent. The results presented in this paper demonstrate the value of selecting solvent-appropriate post-extraction drying methods.
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