ArticleNature communications2021
The main oxidative inactivation pathway of the plant hormone auxin.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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Who cites it
105 citing papers in PubMed, 227 citations in OpenAlex.
- Photoperiod-dependent regulation of secondary growth by auxin flux: how it occurs and how to benefit from it.Biological reviews of the Cambridge Philosophical Society · 2026Review
- 5-Aminolevulinic acid promotes cell division and young fruit development by suppressing the PpARF9-PpGH3.1 auxin-conjugation module in peach.Molecular horticulture · 2026Article
- Metabolism meets transport: a new perspective on auxin homeostasis at subcellular level.Planta · 2026Review
- GH3 phylogenetic subgroups define divergent routes of auxin inactivation via aspartate and glutamine conjugation.Plant physiology · 2026Article
- The Fungal Pathogen Fusarium graminearum Can Hydrolyse Tryptamine-Derived Hydroxy-Cinnamic Acid Amide Defence Compounds, and Generates Highly Increased Auxin Levels in Wheat via Copper Amine-Oxidases.Molecular plant pathology · 2026Article
- Anchoring mechanism-inspired discovery of a bacterial P450 gene conferring resistance to auxin herbicides.Nature communications · 2026Article
- Review
- Genetic Mapping of thePlants (Basel, Switzerland) · 2026Article
- Comprehensive characterisation of IAA inactivation pathways reveals the impact of glycosylation on auxin metabolism and plant development in Arabidopsis.Communications biology · 2026Article
- Phytohormone and transcriptome analyses unravel the molecular mechanisms of heterophylly in Pinellia ternata.BMC plant biology · 2026Article
- Screening of Plant Growth Regulators for Promoting Rooting of Pitaya Cuttings.Plants (Basel, Switzerland) · 2026Article
- Article
- Data Fusion Combining High-Resolution Mass Spectrometry andMolecules (Basel, Switzerland) · 2026Article
- Effects of Fruiting Load on Endogenous Hormones in the Aril of Longan Fruit and Leaflet of Fruiting Branches at the Mature Stage.Plants (Basel, Switzerland) · 2026Article
- Hormone-centric multi-omics atlas of flower and early fruit development in tomato.Plant communications · 2026Article
- Synergistic effect of composite microbial bioactive metabolites in the control of rice diseases and pest insects under reduced-dosage chemical pesticide application.Frontiers in microbiology · 2026Article
- Epigenetic modifications in plant abiotic stress adaptation: towards climate-resilient and sustainable crop improvement.Frontiers in plant science · 2026Review
- Conserved genotype-independent rhizobacteria promote maize growth.NPJ biofilms and microbiomes · 2025Article
- Bacillus endophyticus J13 imparts drought tolerance to Arabidopsis thaliana by regulating the plant auxin-dependent auxin conjugation pathway.Plant cell reports · 2025Article
- Comparative Proteomic Analysis of Self-CompatiblePlant direct · 2025Article
45 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Inactivation of the phytohormone auxin plays important roles in plant development, and several enzymes have been implicated in auxin inactivation. In this study, we show that the predominant natural auxin, indole-3-acetic acid (IAA), is mainly inactivated via the GH3-ILR1-DAO pathway. IAA is first converted to IAA-amino acid conjugates by GH3 IAA-amidosynthetases. The IAA-amino acid conjugates IAA-aspartate (IAA-Asp) and IAA-glutamate (IAA-Glu) are storage forms of IAA and can be converted back to IAA by ILR1/ILL amidohydrolases. We further show that DAO1 dioxygenase irreversibly oxidizes IAA-Asp and IAA-Glu into 2-oxindole-3-acetic acid-aspartate (oxIAA-Asp) and oxIAA-Glu, which are subsequently hydrolyzed by ILR1 to release inactive oxIAA. This work established a complete pathway for the oxidative inactivation of auxin and defines the roles played by auxin homeostasis in plant development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.