Evidence map›Paper›PMID 34810278›Full record

ArticleLife science alliance2022

Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distress.

Carolina Esquer, Oscar Echeagaray, Fareheh Firouzi, Clarissa Savko, Grant Shain, Pria Bose, Abigail Rieder, Sophie Rokaw, Andrea Witon-Paulo, Natalie Gude and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. NAM journal · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Carolina EsquerSan Diego State University Integrated Regenerative Research Institute and Biology Department, San Diego State University, San Diego, CA, USA.
Oscar EcheagaraySan Diego State University Integrated Regenerative Research Institute and Biology Department, San Diego State University, San Diego, CA, USA.
Fareheh FirouziSan Diego State University Integrated Regenerative Research Institute and Biology Department, San Diego State University, San Diego, CA, USA.
Clarissa SavkoSan Diego State University Integrated Regenerative Research Institute and Biology Department, San Diego State University, San Diego, CA, USA.
Grant ShainSan Diego State University Integrated Regenerative Research Institute and Biology Department, San Diego State University, San Diego, CA, USA.
Pria BoseSan Diego State University Integrated Regenerative Research Institute and Biology Department, San Diego State University, San Diego, CA, USA.
Abigail RiederSan Diego State University Integrated Regenerative Research Institute and Biology Department, San Diego State University, San Diego, CA, USA.
Sophie RokawSan Diego State University Integrated Regenerative Research Institute and Biology Department, San Diego State University, San Diego, CA, USA.
Andrea Witon-PauloSan Diego State University Integrated Regenerative Research Institute and Biology Department, San Diego State University, San Diego, CA, USA.
Natalie GudeSan Diego State University Integrated Regenerative Research Institute and Biology Department, San Diego State University, San Diego, CA, USA.
Mark A SussmanSan Diego State University Integrated Regenerative Research Institute and Biology Department, San Diego State University, San Diego, CA, USA heartman4ever@icloud.com.ORCID 0000-0002-0104-4799
San Diego State University · US

Funding

Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NIH HHS S10 OD026929
6 · The paper itself

Abstract

Vaping of flavored liquids has been touted as safe alternative to traditional cigarette smoking with decreased health risks. The popularity of vaping has dramatically increased over the last decade, particularly among teenagers who incorporate vaping into their daily life as a social activity. Despite widespread and increasing adoption of vaping among young adults, there is little information on long-term consequences of vaping and potential health risks. This study demonstrates vaping-induced pulmonary injury using commercial JUUL pens with flavored vape juice using an inhalation exposure murine model. Profound pathological changes to upper airway, lung tissue architecture, and cellular structure are evident within 9 wk of exposure. Marked histologic changes include increased parenchyma tissue density, cellular infiltrates proximal to airway passages, alveolar rarefaction, increased collagen deposition, and bronchial thickening with elastin fiber disruption. Transcriptional reprogramming includes significant changes to gene families coding for xenobiotic response, glycerolipid metabolic processes, and oxidative stress. Cardiac systemic output is moderately but significantly impaired with pulmonary side ventricular chamber enlargement. This vaping-induced pulmonary injury model demonstrates mechanistic underpinnings of vaping-related pathologic injury.

Indexed as

BiomarkersDisease SusceptibilityGene Expression RegulationHumansLung InjuryOxidative StressRespiratory Distress SyndromeVapingBiomarkers

Identifiers

PMID34810278
PMCPMC8616545
OpenAlexW3215568536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.