Evidence map›Paper›PMID 34810264›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis.

Megan R Beggs, Kennedi Young, Wanling Pan, Debbie D O'Neill, Matthew Saurette, Allein Plain, Juraj Rievaj, Michael R Doschak, Emmanuelle Cordat, Henrik Dimke and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Whey Protein Phospholipid Concentrate and Its Fractions as a Diet Intervention Enhance Bone Health and Alter the Gut Microbiome in Weanling Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  8. Review
  9. Article
  10. Calcium-Sensing Receptor in the Thick Ascending Limb and Renal Response to Hypercalcemia.Journal of the American Society of Nephrology : JASN · 2025
    Article
  11. Biology of calcium homeostasis regulation in intestine and kidney.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Magnesium biology.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Review
  18. Establishing the link between D-mannose and juvenile grass carp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024
    Article
  19. Review
  20. Calcium signalling and transport in the kidney.Nature reviews. Nephrology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Megan R BeggsDepartment of Physiology, University of Alberta, Edmonton, AB, T6G 2H7, Canada.ORCID 0000-0002-2690-1785
Kennedi YoungDepartment of Physiology, University of Alberta, Edmonton, AB, T6G 2H7, Canada.
Wanling PanDepartment of Physiology, University of Alberta, Edmonton, AB, T6G 2H7, Canada.
Debbie D O'NeillDepartment of Physiology, University of Alberta, Edmonton, AB, T6G 2H7, Canada.
Matthew SauretteDepartment of Physiology, University of Alberta, Edmonton, AB, T6G 2H7, Canada.
Allein PlainDepartment of Physiology, University of Alberta, Edmonton, AB, T6G 2H7, Canada.ORCID 0000-0001-9841-9499
Juraj RievajDepartment of Physiology, University of Alberta, Edmonton, AB, T6G 2H7, Canada.
Michael R DoschakFaculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2H5, Canada.
Emmanuelle CordatDepartment of Physiology, University of Alberta, Edmonton, AB, T6G 2H7, Canada.
Henrik DimkeDepartment of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark.ORCID 0000-0002-9170-2168
R Todd AlexanderDepartment of Physiology, University of Alberta, Edmonton, AB, T6G 2H7, Canada; todd2@ualberta.ca.ORCID 0000-0001-7396-7894
University of Alberta · CAUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium (Ca

Indexed as

AnimalsCalcification, PhysiologicCalciumCationsClaudinsGenotypeHEK293 CellsHomeostasisHumansHypocalcemiaIn Vitro TechniquesMiceMice, KnockoutPermeabilityCalciumCationsclaudin 12 protein, mouseClaudinsCldn2 protein, mousecalciumclaudinsparacellular

Identifiers

PMID34810264
PMCPMC8694054
OpenAlexW3217468093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.