Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors at 3 institutions in 1 country.
Kelly A McCorkellDepartment of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.
Nipun JayachandranDepartment of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.ORCID 0000-0001-9205-8119
Michelle D CullyDepartment of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.ORCID 0000-0002-3873-4929
Jacquelyn Freund-BrownDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Tiffany WeinkopffDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205.ORCID 0000-0002-5239-2486
James MonslowDepartment of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.
Yinling HuCenter for Cancer Research, National Cancer Institute, Frederick, MD 21702.ORCID 0000-0002-4795-8537
Ellen PuréDepartment of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.ORCID 0000-0003-2107-3711
Bruce D FreedmanDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.ORCID 0000-0003-4487-7210
Jorge I AlvarezDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.
Michael P CancroDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-8659-3227
Michael J MayDepartment of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104; maym@vet.upenn.edu.ORCID 0000-0002-2485-3716
University of Pennsylvania · USNational Cancer Institute · USUniversity of Arkansas for Medical Sciences · US
Funding
Immune System Development and RegulationT32AI055428 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M, OLIVER, PAULA MARIA · 2003 to 2025
$4.2M
Non-Canonical NF-kappaB Signaling In Endothelial CellsR01HL080612 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MAY, MICHAEL J · 2006 to 2010
$2.0M
Endothelial Cell-Intrinsic Non-Canonical NF-kB in Chronic inflammationR01AR066567 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MAY, MICHAEL J · 2017 to 2021
$1.9M
Targeting NF-kB in AtherosclerosisR01HL096642 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MAY, MICHAEL J · 2011 to 2014
Global inactivation of IκB kinase (IKK)-α results in defective lymph node (LN) formation and B cell maturation, and loss of IKK-α-dependent noncanonical NF-κB signaling in stromal organizer and hematopoietic cells is thought to underlie these distinct defects. We previously demonstrated that this pathway is also activated in vascular endothelial cells (ECs). To determine the physiologic function of EC-intrinsic IKK-α, we crossed
Indexed as
AnimalsB-LymphocytesCell LineEndothelial CellsFemaleHomeostasisI-kappa B KinaseI-kappa B ProteinsLymph NodesLymphoid TissueMaleMiceMice, Inbred C57BLNF-kappa BNF-KappaB Inhibitor alphaOrganogenesisI-kappa B KinaseI-kappa B ProteinsNF-kappa BNF-KappaB Inhibitor alphaProtein Serine-Threonine KinasesTumor Necrosis Factor-alphaB cellendothelial celllymphaticlymph nodeNF-κB
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell-derived compartments. · full record | OpenQuestion