Evidence map›Paper›PMID 34810248›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release.

Kevin C Courtney, Jason D Vevea, Yueqi Li, Zhenyong Wu, Zhao Zhang, Edwin R Chapman

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Alternative splicing of synaptotagmin 7 regulates oligomerization and short-term synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Concordant transcriptional and morphological remodeling revealed bybioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Phospholipids Differentially Regulate CaACS chemical biology · 2024
    Article
  10. Article
  11. Article
  12. The juxtamembrane linker of synaptotagmin 1 regulates CabioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. The Core Complex of the CaJournal of molecular biology · 2023
    Review
  18. Otoferlin as a multirole CaFrontiers in cellular neuroscience · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kevin C CourtneyHHMI, University of Wisconsin, Madison, WI 53705.ORCID 0000-0003-1315-4917
Jason D VeveaHHMI, University of Wisconsin, Madison, WI 53705.ORCID 0000-0002-3068-973X
Yueqi LiHHMI, University of Wisconsin, Madison, WI 53705.
Zhenyong WuHHMI, University of Wisconsin, Madison, WI 53705.
Zhao ZhangHHMI, University of Wisconsin, Madison, WI 53705.
Edwin R ChapmanHHMI, University of Wisconsin, Madison, WI 53705; chapman@wisc.edu.ORCID 0000-0001-9787-8140
University of Wisconsin–Madison · USUniversity of Science and Technology of China · CN

Funding

Synaptotagmin C2B Domain as a Ca2+ Sensing ModuleR01MH061876 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Edwin R Chapman · 2002 to 2026
$7.7M
Structure and dynamics of exocytotic fusion poresR35NS097362 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI CHAPMAN, EDWIN R · 2017 to 2024
$4.6M
Howard Hughes Medical InstituteNIMH NIH HHS R01 MH061876NINDS NIH HHS R35 NS097362
6 · The paper itself

Abstract

Synaptotagmin 1 (syt1) is a Ca

Indexed as

AnimalsCalciumCytoplasmElectrophysiologyExocytosisIn Vitro TechniquesLightLipid BilayersLipidsLysineMembrane FusionMicroscopy, Atomic ForceNeuronsNeurotransmitter AgentsPhospholipidsPresynaptic TerminalsCalciumLipid BilayersLipidsLysineNeurotransmitter AgentsPhospholipidsRecombinant ProteinsSynaptotagmin ISYT1 protein, humanSyt1 protein, ratexocytosisneurotransmissionoligomerizationsynaptotagmin

Identifiers

PMID34810248
PMCPMC8694047
OpenAlexW3217215493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.