Evidence map›Paper›PMID 34810232›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons.

Sana Al Awabdh, Florian Donneger, Marie Goutierre, Martial Séveno, Oana Vigy, Pauline Weinzettl, Marion Russeau, Imane Moutkine, Sabine Lévi, Philippe Marin and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Enhancing KCC2 function reduces interictal activity and prevents seizures in temporal lobe epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Bidirectional Regulation of GABALife (Basel, Switzerland) · 2024
    Review
  9. Therapeutic potential for KCC2-targeted neurological diseases.The Japanese dental science review · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Chloride imbalance in Fragile X syndrome.Frontiers in neuroscience · 2022
    Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Sana Al AwabdhINSERM UMR-S 1270, 75005 Paris, France.
Florian DonnegerINSERM UMR-S 1270, 75005 Paris, France.
Marie GoutierreINSERM UMR-S 1270, 75005 Paris, France.
Martial SévenoBCM, Université de Montpellier, CNRS, INSERM, 34094 Montpellier, France.ORCID 0000-0002-5000-8735
Oana VigyIGF, Université de Montpellier, CNRS, INSERM, 34090 Montpellier, France.
Pauline WeinzettlINSERM UMR-S 1270, 75005 Paris, France.
Marion RusseauINSERM UMR-S 1270, 75005 Paris, France.
Imane MoutkineINSERM UMR-S 1270, 75005 Paris, France.
Sabine LéviINSERM UMR-S 1270, 75005 Paris, France.
Philippe MarinIGF, Université de Montpellier, CNRS, INSERM, 34090 Montpellier, France.ORCID 0000-0002-5977-7274
Jean Christophe PoncerINSERM UMR-S 1270, 75005 Paris, France jean-christophe.poncer@inserm.fr.ORCID 0000-0001-5729-3009
Inserm · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The K

Indexed as

AnimalsCell MembraneCerebral CortexGABAergic NeuronsK Cl- CotransportersMaleMembrane ProteinsNeuronsRatsRats, Sprague-DawleyReceptors, GABA-ASymportersSynapsesSynaptic TransmissiongephyrinK Cl- CotransportersMembrane ProteinsReceptors, GABA-ASymporterscerebral cortexchlorideGABA transmissionKCC2proteomicssynaptic transmission

Identifiers

PMID34810232
PMCPMC8802937
OpenAlexW3216981901

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.