Evidence map›Paper›PMID 34810231›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Microglial Correlates of Late Life Physical Activity: Relationship with Synaptic and Cognitive Aging in Older Adults.

Kaitlin B Casaletto, Cutter A Lindbergh, Anna VandeBunte, John Neuhaus, Julie A Schneider, Aron S Buchman, William G Honer, David A Bennett

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  5. Moderating effects of plasma glial fibrillary acidic protein along the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
  7. Review
  8. Neuroinflammation in Alzheimer disease.Nature reviews. Immunology · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Sex and gender differences in cognitive resilience to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  14. Article
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kaitlin B CasalettoDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, California 94158 Kaitlin.casaletto@ucsf.edu.
Cutter A LindberghDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030.
Anna VandeBunteDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, California 94158.
John NeuhausDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, California 94158.
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612.
Aron S BuchmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612.
William G HonerBritish Columbia Mental Health and Substance Use Services Research Institute, Vancouver, V6T 1Z4, British Columbia Canada.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612.
Rush University Medical Center · USUniversity of British Columbia · CAUniversity of Connecticut · US

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Unraveling the intersection of synaptic biology, lifestyle, and cognitive resilienceR01AG072475 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2021 to 2025
$4.3M
Can Behavior Shape Neural Health? Identifying Modifiable Factors to Prevent Cognitive Decline in AgeK23AG058752 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2018 to 2022
$994k
NIA NIH HHS K23 AG058752NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG072475
6 · The paper itself

Abstract

Physical activity relates to reduced dementia risk, but the cellular and molecular mechanisms are unknown. We translated animal and

Indexed as

Adaptor Proteins, Vesicular TransportAgedAged, 80 and overAgingBrainCognitive AgingExerciseFemaleHumansMaleMicrogliaNerve Tissue ProteinsQa-SNARE ProteinsSynapsesSynapsinsSynaptophysinAdaptor Proteins, Vesicular Transportcomplexin INerve Tissue ProteinsQa-SNARE ProteinsSynapsinsSynaptophysinSynaptotagminsAlzheimer's diseaseexerciseHLAmajor histocompatibility complex II

Identifiers

PMID34810231
PMCPMC8802938
OpenAlexW3216946222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.