Evidence map›Paper›PMID 34810174›Full record

ArticleEvidence-based mental health2022

Antipsychotic use in pregnancy and risk of attention/deficit-hyperactivity disorder and autism spectrum disorder: a Nordic cohort study.

Óskar Hálfdánarson, Jacqueline M Cohen, Øystein Karlstad, Carolyn E Cesta, Marte-Helene Bjørk, Siri Eldevik Håberg, Kristjana Einarsdóttir, Kari Furu, Mika Gissler, Vidar Hjellvik and 7 more

Abstract read
In one paragraph

Article in Evidence-based mental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Systematic Review: Antipsychotic Medication in Pregnancy and Neurodevelopmental Outcomes in Children.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Pooled it
  2. Pooled it
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Óskar HálfdánarsonCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.ORCID 0000-0002-4564-6126
Jacqueline M CohenCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-7300-0488
Øystein KarlstadDepartment of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0003-1204-787X
Carolyn E CestaCentre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-5759-9366
Marte-Helene BjørkDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.ORCID 0000-0002-5745-1094
Siri Eldevik HåbergCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-2199-5225
Kristjana EinarsdóttirCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.ORCID 0000-0003-4931-7650
Kari FuruCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0003-2245-0179
Mika GisslerFinnish Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0001-8254-7525
Vidar HjellvikDepartment of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-2379-9906
Helle KielerCentre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-9338-7133
Maarit K LeinonenFinnish Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0002-7631-4749
Mette NørgaardDepartment of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-6110-5891
Buket Öztürk EssenDepartment of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Sinna Pilgaard UlrichsenDepartment of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-8679-5163
Johan ReutforsCentre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1372-4262
Helga ZoegaCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland h.zoega@unsw.edu.au.ORCID 0000-0003-0761-9028

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntipsychotics are increasingly used among women of childbearing age and during pregnancy.

objectiveTo determine whether children exposed to antipsychotics

findingsAmong 4 324 086 singleton births, 15 466 (0.4%) were exposed to antipsychotics DISCUSSION: Our findings suggest little or no increased risk of child ADHD or ASD after CLINICAL IMPLICATIONS: Results regarding child neurodevelopment are reassuring for women who need antipsychotics during pregnancy.

Indexed as

Antipsychotic AgentsAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderPrenatal Exposure Delayed EffectsAttentionChildCohort StudiesFemaleHumansMalePregnancyAntipsychotic Agentsadult psychiatrychild & adolescent psychiatrypsychiatryschizophrenia & psychotic disorders

Identifiers

PMID34810174
PMCPMC9046752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.