Evidence map›Paper›PMID 34809702›Full record

ArticleAntimicrobial resistance and infection control2021

Infection prevention strategies are highly protective in COVID-19 units while main risks to healthcare professionals come from coworkers and the community.

Shruti K Gohil, Kathleen A Quan, Keith M Madey, Suzanne King-Adelsohn, Tom Tjoa, Delia Tifrea, Bridgit O Crews, Edwin S Monuki, Saahir Khan, Sebastian D Schubl and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial resistance and infection control, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Shruti K GohilEpidemiology and Infection Prevention Program, Irvine Health (UC Irvine Health), University of California, Irvine, USA. skgohil@hs.uci.edu.
Kathleen A QuanEpidemiology and Infection Prevention Program, Irvine Health (UC Irvine Health), University of California, Irvine, USA.
Keith M MadeyEpidemiology and Infection Prevention Program, Irvine Health (UC Irvine Health), University of California, Irvine, USA.
Suzanne King-AdelsohnPathology and Laboratory Medicine, UCI Health, Newport Beach, USA.
Tom TjoaDivision of Infectious Diseases, Department of Medicine, Irvine School of Medicine, University of California, 100 Theory, Suite 120, Irvine, CA, 92617, USA.
Delia TifreaPathology and Laboratory Medicine, UCI Health, Newport Beach, USA.
Bridgit O CrewsPathology and Laboratory Medicine, UCI Health, Newport Beach, USA.
Edwin S MonukiPathology and Laboratory Medicine, UCI Health, Newport Beach, USA.
Saahir KhanDivision of Infectious Diseases, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Sebastian D SchublDepartment of Surgery, Irvine School of Medicine, University of California, Irvine, USA.
Cassiana E BittencourtPathology and Laboratory Medicine, UCI Health, Newport Beach, USA.
Neil DetweilerPathology and Laboratory Medicine, UCI Health, Newport Beach, USA.
Wayne ChangDivision of Occupational and Environmental Medicine, Irvine School of Medicine, University of California, Irvine, USA.
Lynn WillisEpidemiology and Infection Prevention Program, Irvine Health (UC Irvine Health), University of California, Irvine, USA.
Usme KhusbuEpidemiology and Infection Prevention Program, Irvine Health (UC Irvine Health), University of California, Irvine, USA.
Antonella SaturnoEpidemiology and Infection Prevention Program, Irvine Health (UC Irvine Health), University of California, Irvine, USA.
Sherif A RezkPathology and Laboratory Medicine, UCI Health, Newport Beach, USA.
Cesar FigueroaDepartment of Surgery, Irvine School of Medicine, University of California, Irvine, USA.
Aarti JainDepartment of Physiology and Biophysics, University of California, Irvine, USA.
Rafael AssisDepartment of Physiology and Biophysics, University of California, Irvine, USA.
Philip FelgnerDepartment of Physiology and Biophysics, University of California, Irvine, USA.
Robert EdwardsPathology and Laboratory Medicine, UCI Health, Newport Beach, USA.
Lanny HsiehDivision of Infectious Diseases, Department of Medicine, Irvine School of Medicine, University of California, 100 Theory, Suite 120, Irvine, CA, 92617, USA.
Donald ForthalDivision of Infectious Diseases, Department of Medicine, Irvine School of Medicine, University of California, 100 Theory, Suite 120, Irvine, CA, 92617, USA.
William C WilsonChief Medical Officer, UC Irvine Health, Orange, USA.
Michael J StamosDepartment of Surgery, Irvine School of Medicine, University of California, Irvine, USA.
Susan S HuangEpidemiology and Infection Prevention Program, Irvine Health (UC Irvine Health), University of California, Irvine, USA.

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
NCATS NIH HHS KL2 TR001416NCATS NIH HHS UL1 TR001414
6 · The paper itself

Abstract

backgroundEarly evaluations of healthcare professional (HCP) COVID-19 risk occurred during insufficient personal protective equipment and disproportionate testing, contributing to perceptions of high patient-care related HCP risk. We evaluated HCP COVID-19 seropositivity after accounting for community factors and coworker outbreaks.

methodsPrior to universal masking, we conducted a single-center retrospective cohort plus cross-sectional study. All HCP (1) seen by Occupational Health for COVID-like symptoms (regardless of test result) or assigned to (2) dedicated COVID-19 units, (3) units with a COVID-19 HCP outbreak, or (4) control units from 01/01/2020 to 04/15/2020 were offered serologic testing by an FDA-authorized assay plus a research assay against 67 respiratory viruses, including 11 SARS-CoV-2 antigens. Multivariable models assessed the association of demographics, job role, comorbidities, care of a COVID-19 patient, and geocoded socioeconomic status with positive serology.

resultsOf 654 participants, 87 (13.3%) were seropositive; among these 60.8% (N = 52) had never cared for a COVID-19 patient. Being male (OR 1.79, CI 1.05-3.04, p = 0.03), working in a unit with a HCP-outbreak unit (OR 2.21, CI 1.28-3.81, p < 0.01), living in a community with low owner-occupied housing (OR = 1.63, CI = 1.00-2.64, p = 0.05), and ethnically Latino (OR 2.10, CI 1.12-3.96, p = 0.02) were positively-associated with COVID-19 seropositivity, while working in dedicated COVID-19 units was negatively-associated (OR 0.53, CI = 0.30-0.94, p = 0.03). The research assay identified 25 additional seropositive individuals (78 [12%] vs. 53 [8%], p < 0.01).

conclusionsPrior to universal masking, HCP COVID-19 risk was dominated by workplace and community exposures while working in a dedicated COVID-19 unit was protective, suggesting that infection prevention protocols prevent patient-to-HCP transmission. Prior to universal masking, HCP COVID-19 risk was dominated by workplace and community exposures while working in a dedicated COVID-19 unit was protective, suggesting that infection prevention protocols prevent patient-to-HCP transmission.

Indexed as

Health PersonnelInfection ControlAcademic Medical CentersAdultCaliforniaCommunity-Acquired InfectionsCOVID-19Cross-Sectional StudiesDisease OutbreaksFemaleHumansInfectious Disease Transmission, Patient-to-ProfessionalMaleMiddle AgedMultivariate AnalysisRegression AnalysisCOVID-19 outbreaksCOVID-19 seroprevalenceHealthcare professional COVID-19 exposureHealthcare worker COVID-19 exposureSevere acute respiratory syndrome coronavirus-2

Identifiers

PMID34809702
PMCPMC8608236

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.