Evidence map›Paper›PMID 34809623›Full record

ArticleJournal of nanobiotechnology2021

Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization.

Zhe Wang, Zihuai Zhou, Jiayan Fan, Leiqing Zhang, Zhixin Zhang, Zhifang Wu, Ying Shi, Haiyan Zheng, Zhengyi Zhang, Ruikang Tang and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  8. Research progress of biomimetic materials in oral medicine.Journal of biological engineering · 2023
    Review
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  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Zhe Wang *Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Engineering Research Center for Oral Biomaterials and Devices, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China.
Zihuai Zhou *Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Engineering Research Center for Oral Biomaterials and Devices, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China.
Jiayan FanStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Engineering Research Center for Oral Biomaterials and Devices, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China.
Leiqing ZhangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Engineering Research Center for Oral Biomaterials and Devices, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China.
Zhixin ZhangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Engineering Research Center for Oral Biomaterials and Devices, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China.
Zhifang WuStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Engineering Research Center for Oral Biomaterials and Devices, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China.
Ying ShiStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Engineering Research Center for Oral Biomaterials and Devices, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China.
Haiyan ZhengStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Engineering Research Center for Oral Biomaterials and Devices, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China.
Zhengyi ZhangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Engineering Research Center for Oral Biomaterials and Devices, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China.
Ruikang TangDepartment of Chemistry, Zhejiang University, Hangzhou, 310027, Zhejiang, China.
Baiping FuStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Engineering Research Center for Oral Biomaterials and Devices, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China. fbp@zju.edu.cn.ORCID http://orcid.org/0000-0002-1284-8290
Stomatology Hospital · CNZhejiang Cancer Hospital · CNZhejiang University · CN

Funding

National Natural Science Foundation of China 81970982National Natural Science Foundation of China 82001097Natural Science Foundation of Zhejiang Province 2020C03037Natural Science Foundation of Zhejiang Province LQ20H140005
6 · The paper itself

Abstract

Demineralization of hard tooth tissues leads to dental caries, which cause health problems and economic burdens throughout the world. A biomimetic mineralization strategy is expected to reverse early dental caries. Commercially available anti-carious mineralizing products lead to inconclusive clinical results because they cannot continuously replenish the required calcium and phosphate resources. Herein, we prepared a mineralizing film consisting of hydroxypropylmethylcellulose (HPMC) and polyaspartic acid-stabilized amorphous calcium phosphate (PAsp-ACP) nanoparticles. HPMC which contains multiple hydroxyl groups is a film-forming material that can be desiccated to form a dry film. In a moist environment, this film gradually changes into a gel. HPMC was used as the carrier of PAsp-ACP nanoparticles to deliver biomimetic mineralization. Our results indicated that the hydroxyl and methoxyl groups of HPMC could assist the stability of PAsp-ACP nanoparticles and maintain their biomimetic mineralization activity. The results further demonstrated that the bioinspired mineralizing film induced the early mineralization of demineralized dentin after 24 h with increasing mineralization of the whole demineralized dentin (3-4 µm) after 72-96 h. Furthermore, these results were achieved without any cytotoxicity or mucosa irritation. Therefore, this mineralizing film shows promise for use in preventive dentistry due to its efficient mineralization capability.

Indexed as

Biomimetic MaterialsCalcium PhosphatesHypromellose DerivativesAnimalsCells, CulturedDental CariesDentinHumansHydrogelsMaleMiceNanoparticle Drug Delivery SystemNanoparticlesRabbitsTooth Calcificationamorphous calcium phosphateCalcium PhosphatesHydrogelsHypromellose DerivativesNanoparticle Drug Delivery SystemBiomimetic mineralizationCollagenDental cariesDentinFilmHydroxypropylmethylcellulose

Identifiers

PMID34809623
PMCPMC8607665
OpenAlexW3217043978

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.