Evidence map›Paper›PMID 34809618›Full record

ArticleJournal of nanobiotechnology2021

Macrophage-biomimetic porous Se@SiO

Cheng Ding, Chuang Yang, Tao Cheng, Xingyan Wang, Qiaojie Wang, Renke He, Shang Sang, Kechao Zhu, Dongdong Xu, Jiaxing Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Review
  3. Clusterzymes-driven therapy: ultrasmall CuJournal of nanobiotechnology · 2026
    Article
  4. Review
  5. FeCurrent cancer drug targets · 2026
    Article
  6. Biocompatible Mesoporous Materials for Bone Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Porous Se@SiOMolecular medicine (Cambridge, Mass.) · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Cheng Ding *Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
Chuang Yang *Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
Tao Cheng *Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
Xingyan WangCollege of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China.
Qiaojie WangDepartment of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
Renke HeDepartment of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
Shang SangDepartment of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
Kechao ZhuDepartment of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
Dongdong XuDepartment of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
Jiaxing WangDepartment of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China. jxwang@shsmu.edu.cn.
Xijian LiuCollege of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China. liuxijian@sues.edu.cn.
Xianlong ZhangDepartment of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China. dr_zhangxianlong@163.com.ORCID http://orcid.org/0000-0003-2122-9990
Shanghai Jiao Tong University · CNShanghai University of Engineering Science · CN

Funding

National Natural Science Foundation of China 81772309National Natural Science Foundation of China 81974324Shanghai Pujiang Talent Program 18PJD035
6 · The paper itself

Abstract

backgroundInflammatory osteolysis, a major complication of total joint replacement surgery, can cause prosthesis failure and necessitate revision surgery. Macrophages are key effector immune cells in inflammatory responses, but excessive M1-polarization of dysfunctional macrophages leads to the secretion of proinflammatory cytokines and severe loss of bone tissue. Here, we report the development of macrophage-biomimetic porous SiO

resultsMacrophage membrane-coated porous Se@SiO

conclusionOur findings suggest that M-Se@SiO

Indexed as

Biomimetic MaterialsImmunologic FactorsMacrophagesAnimalsCoated Materials, BiocompatibleCytokinesDisease Models, AnimalImmunotherapyMiceNanocompositesOsteolysisPorosityRAW 264.7 CellsSeleniumSilicon DioxideCoated Materials, BiocompatibleCytokinesImmunologic FactorsSeleniumSilicon DioxideBiomimetic nanoparticleImmunomodulationMacrophage polarizationOsteolysisPorous Se@SiO2 nanospheres

Identifiers

PMID34809618
PMCPMC8607681
OpenAlexW3201360842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.