ArticleBMC emergency medicine2021
Monocyte distribution width (MDW) as a new tool for the prediction of sepsis in critically ill patients: a preliminary investigation in an intensive care unit.
Article in BMC emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Monocyte Distribution Width for Sepsis Diagnosis in the Emergency Department and Intensive Care Unit: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Pooled it
- Article
- Diagnostic accuracy and severity prediction of monocyte distribution width in sepsis: a retrospective study from the United Arab Emirates.Frontiers in medicine · 2026Article
- Monocyte Anisocytosis Can Discriminate Between Sepsis and Sterile Inflammation, but not Mortality, in Critically Ill Surgical/Trauma Patients: A Secondary Prospective Analysis.Critical care explorations · 2025Observational
- Biomarkers to guide sepsis management.Annals of intensive care · 2025Review
- Diagnostic Performance of Monocyte Distribution Width for the Detection of Sepsis: A Systematic Review and Meta-Analysis.Journal of the American College of Emergency Physicians open · 2025Review
- The Role of Monocyte Distribution Width (MDW) in the Prediction of Death in Adult Patients with Sepsis.Microorganisms · 2025Article
- Monocyte distribution width enhances the detection of infection in patients after primary percutaneous coronary intervention.PloS one · 2025Article
- The Need for Standardized Guidelines for the Use of Monocyte Distribution Width (MDW) in the Early Diagnosis of Sepsis.Journal of personalized medicine · 2024Review
- Decoding Inflammation: Predicting Sepsis in the ICU.Cureus · 2024Article
- Clinical usefulness of presepsin and monocyte distribution width (MDW) kinetic for predicting mortality in critically ill patients in intensive care unit.Frontiers in medicine · 2024Article
- Utility of monocyte distribution width in the differential diagnosis between simple and complicated diverticulitis: a retrospective cohort study.BMC gastroenterology · 2023Article
- Prognostic Role of Monocyte Distribution Width, CRP, Procalcitonin and Lactate as Sepsis Biomarkers in Critically Ill COVID-19 Patients.Journal of clinical medicine · 2023Article
- Advances in the Study of Immunosuppressive Mechanisms in Sepsis.Journal of inflammation research · 2023Review
- Monocyte Distribution Width as a predictor of community acquired sepsis in patients prospectively enrolled at the Emergency Department.BMC infectious diseases · 2022Observational
- Reliability of predictive models to support early decision making in the emergency department for patients with confirmed diagnosis of COVID-19: the Pescara Covid Hospital score.BMC health services research · 2022Article
- Advances in Immune Monitoring Approaches for Sepsis-Induced Immunosuppression.Frontiers in immunology · 2022Review
- Diagnostic and Prognostic Value of Monocyte Distribution Width in Sepsis.Journal of inflammation research · 2022Review
- Monocyte Distribution Width (MDW) as a useful and cost-effective biomarker for sepsis prediction.Journal of circulating biomarkersArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMonocyte Distribution Width (MDW), a simple proxy marker of innate monocyte activation, can be used for the early recognition of sepsis along with Procalcitonin. This study explored the added value of MDW as an early predictor of ensuing sepsis in patients hospitalised in an Intensive Care Unit.
methodsWe performed an observational prospective monocentric study to estimate the analytical performance of MDW in detecting ensuing sepsis in a sample of consecutive patients assisted in an Intensive Care Unit for > 48 h for any reason. Demographic and clinical characteristics, past medical history and other laboratory measurements were included as potential predictors of confirmed sepsis in multivariate logistic regression.
resultsA total of 211 patients were observed, 129 of whom were included in the final sample due to the suspect of ensuing sepsis; of these, 74 (57%) had a confirmed diagnosis of sepsis, which was best predicted with the combination of MDW > 23.0 and PCT > 0.5 ng/mL (Positive Predictive Value, PPV: 92.6, 95% CI: 82.1-97.9). The best MDW cut-off to rule out sepsis was ≤20.0 (Negative Predictive Value, NPV: 86.4, 95% CI: 65.1-97.1). Multivariate analyses using both MDW and PCT found a significant association for MDW > 23 only (OR:17.64, 95% CI: 5.53-67.91).
conclusionWe found that values of MDW > 23 were associated with a high PPV for sepsis, whereas values of MDW ≤ 20 were associated with a high NPV. Our findings suggest that MDW may help clinicians to monitor ICU patients at risk of sepsis, with minimal additional efforts over standard of care.
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