ArticleArteriosclerosis, thrombosis, and vascular biology2022
Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia.
Victoria Osinski, Prasad Srikakulapu, Young Min Haider, Melissa A Marshall, Vijay C Ganta, Brian H Annex, Coleen A McNamara
Article in Arteriosclerosis, thrombosis, and vascular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
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3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it
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3 citing papers in PubMed, 4 citations in OpenAlex.
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5 · Who and what money
Authors and funding
7 authors at 3 institutions in 2 countries.
Victoria OsinskiRobert M. Berne Cardiovascular Research Center (V.O., C.A.M.), University of Virginia.
Prasad SrikakulapuBeirne B. Carter Center for Immunology Research (P.S., Y.M.H., M.A.M., C.A.M.), University of Virginia.
Young Min HaiderBeirne B. Carter Center for Immunology Research (P.S., Y.M.H., M.A.M., C.A.M.), University of Virginia.
Melissa A MarshallBeirne B. Carter Center for Immunology Research (P.S., Y.M.H., M.A.M., C.A.M.), University of Virginia.
Vijay C GantaVascular Biology Center (V.C.G., B.H.A.), Augusta University, GA.
Brian H AnnexVascular Biology Center (V.C.G., B.H.A.), Augusta University, GA.
Coleen A McNamaraRobert M. Berne Cardiovascular Research Center (V.O., C.A.M.), University of Virginia.
Carter Center · USAugusta University · USUniversity of Bern · CH
Funding
BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Systems Biology of Angiogenesis in Peripheral Arterial DiseaseR01HL101200 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POPEL, ALEKSANDER S. · 2010 to 2022
$10.7M
Training in Mechanisms of Cardiovascular DiseasesT32HL072742 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TOBACMAN, LARRY S · 2003 to 2013
$3.7M
Local B-1 Regulation of AtherosclerosisR01HL136098 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2017 to 2020
$3.1M
Clinical Phenotyping and Disease Specific Sampling to Identify Non-coding RNAs for Human Therapeutics in PADR01HL150003 · NHLBI · AUGUSTA UNIVERSITY · PI ANNEX, BRIAN H, MCCLUNG, JOSEPH MATTHEW · 2020 to 2023
$3.0M
Precision Medicine for Therapeutic Angiogenesis in Peripheral Arterial Disease: Targeting of the IL21R PathwayR01HL148590 · NHLBI · AUGUSTA UNIVERSITY · PI ANNEX, BRIAN H · 2019 to 2022
$2.9M
The Anti-angiogenic VEGF165b and VEGFR1 Signaling in Peripheral Artery DiseaseR01HL141325 · NHLBI · UNIVERSITY OF VIRGINIA · PI ANNEX, BRIAN H · 2019 to 2022
$2.7M
Id3 and VSMC in Murine and Human AtherosclerosisR01HL148109 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2019 to 2022
$2.7M
New Roles for VEGFR1 in AngiogenesisR01GM129074 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI MAC GABHANN, FEILIM C · 2018 to 2021
$2.6M
Training Program in Cardiac InnovationT32HL144472 · NHLBI · UNIVERSITY OF MINNESOTA · PI Peter A Crawford, SAMUEL C DUDLEY · 2019 to 2026
$2.6M
Somatic TET2 mutation-driven clonal hematopoiesis in atherosclerosisR01HL141123 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2018 to 2022
$2.0M
A Two Amino Acid Switch in the Anti-angiogenic VEGF165b isoform creates a Novel Agent for Therapeutic Angiogenesis in Peripheral Artery DiseaseR01HL146673 · NHLBI · UNIVERSITY OF VIRGINIA · PI GANTA, VIJAY CHAITANYA · 2019 to 2023
objectiveNeovascularization can maintain and even improve tissue perfusion in the setting of limb ischemia during peripheral artery disease. The molecular and cellular mechanisms mediating this process are incompletely understood. We investigate the potential role(s) for Id3 (inhibitor of differentiation 3) in regulating blood flow in a murine model of hindlimb ischemia (HLI). Approach and Results: HLI was modeled through femoral artery ligation and resection and blood flow recovery was quantified by laser Doppler perfusion imaging. Mice with global Id3 deletion had significantly impaired perfusion recovery at 14 and 21 days of HLI. Endothelial- or myeloid cell-specific deletion of Id3 revealed no effect on perfusion recovery while B-cell-specific knockout of Id3 (Id3
conclusionsThis study is the first to demonstrate a role for B-cell-specific Id3 in maintaining blood flow recovery during HLI. Results suggest a role for Id3 in promoting blood flow during HLI and limiting IgM-expressing B-1b cell expansion. These findings present new mechanisms to investigate in peripheral artery disease pathogenesis.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia. · full record | OpenQuestion