Evidence map›Paper›PMID 34809436›Full record

ReviewAnnual review of medicine2022

Fatty Liver Disease: Diagnosis and Stratification.

Yedidya Saiman, Andres Duarte-Rojo, Mary E Rinella

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Endoscopic sleeve gastrectomyWorld journal of gastrointestinal pharmacology and therapeutics · 2025
    Review
  10. Review
  11. Article
  12. Article
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  14. Article
  15. Epigenetic regulation of NAFLD: A preclinical study.The Indian journal of medical research · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Yedidya SaimanDepartment of Medicine, Section of Hepatology, Lewis Katz School of Medicine at Temple University, Temple University Hospital, Philadelphia, Pennsylvania 19140.
Andres Duarte-RojoDivision of Gastroenterology, Hepatology and Nutrition; Starzl Transplantation Institute; and Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
Mary E RinellaDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA; email: maryrinella68@gmail.com.
Northwestern University · USTemple University Hospital · USUniversity of Pittsburgh · US

Funding

Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVID A GELLER · 2019 to 2026
$10.9M
NIDDK NIH HHS P30 DK120531
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a major public health crisis affecting approximately 25% of the world's population. The spectrum of NAFLD ranges from bland steatosis to steatohepatitis with fibrosis; eventual development of cirrhosis in a subgroup of patients now represents the leading indication for liver transplant in women and in individuals older than 65. The development of noninvasive liver disease assessment tools has led to substantial progress in the diagnosis of NAFLD. Patients with NAFLD are at increased risk of cardiometabolic disease, which should therefore be an important part of the therapeutic approach. This review focuses on diagnosis and risk stratification of NAFLD across the full spectrum of disease, including important considerations in the approach to patients with cirrhosis.

Indexed as

Liver TransplantationNon-alcoholic Fatty Liver DiseaseFemaleFibrosisHumansLiver Cirrhosiscirrhosisfatty liverNAFLDNASHNILDAnonalcoholic fatty liver diseasenonalcoholic steatohepatitisnoninvasive liver disease assessment

Identifiers

PMID34809436
PMCPMC10074159
OpenAlexW3217527542

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.