Evidence map›Paper›PMID 34808708›Full record

ReviewSingapore medical journal2023

A review of COVID-19 vaccination and the reported cardiac manifestations.

Jamie Sin Ying Ho, Ching-Hui Sia, Jinghao Nicholas Ngiam, Poay Huan Loh, Nicholas Wen Sheng Chew, William Kok-Fai Kong, Kian-Keong Poh

Abstract readReview
In one paragraph

Review in Singapore medical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. New and emerging drivers of ambulance demand.BMC emergency medicine · 2026
    Article
  3. Article
  4. Ventricular arrhythmia burden in ICD patients during the second wave of the COVID-19 pandemic.Clinical research in cardiology : official journal of the German Cardiac Society · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Co-VAN study: COVID-19 vaccine associated neurological diseases- an experience from an apex neurosciences centre and review of the literature.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2023
    Review
  10. Article
  11. Distinct Features of Vascular Diseases in COVID-19.Journal of inflammation research · 2023
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Link between COVID-19 vaccines and myocardial infarction.World journal of clinical cases · 2022
    Article
  17. Article
  18. Resilience amidst winds of change.Singapore medical journal · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jamie Sin Ying HoAcademic Foundation Programme, Royal Free London NHS Trust, London, UK.
Ching-Hui SiaDepartment of Cardiology, National University Heart Centre Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jinghao Nicholas NgiamDivision of Infectious Diseases, Department of Medicine, National University Health System, Singapore.
Poay Huan LohDepartment of Cardiology, National University Heart Centre Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Nicholas Wen Sheng ChewDepartment of Cardiology, National University Heart Centre Singapore, Singapore.
William Kok-Fai KongDepartment of Cardiology, National University Heart Centre Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Kian-Keong PohDepartment of Cardiology, National University Heart Centre Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Singapore, 9.03 million doses of the mRNA COVID-19 vaccines by Pfizer-BioNTech and Moderna have been administered, and 4.46 million people are fully vaccinated. An additional 87,000 people have been vaccinated with vaccines in World Health Organization's Emergency Use Listing. The aim of this review is to explore the reported cardiac adverse events associated with different types of COVID-19 vaccines. A total of 42 studies that reported cardiac side effects after COVID-19 vaccination were included in this study. Reported COVID-19 vaccine-associated cardiac adverse events were mainly myocarditis and pericarditis, most commonly seen in adolescent and young adult male individuals after mRNA vaccination. Reports of other events such as acute myocardial infarction, arrhythmia and stress cardiomyopathy were rare. Outcomes of post-vaccine myocarditis and pericarditis were good. Given the good vaccine efficacy and the high number of cases of infection, hospitalisation and death that could potentially be prevented, COVID-19 vaccine remains of overall benefit, based on the current available data.

Indexed as

COVID-19COVID-19 VaccinesMyocarditisPericarditisAdolescentHumansMaleRNA, MessengerVaccinationYoung AdultCOVID-19 VaccinesRNA, MessengerCardiac side effectsCOVID-19myocarditispericarditisvaccination

Identifiers

PMID34808708
PMCPMC10564100

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.