ArticleCerebrovascular diseases extra2021
Long-Term Cognitive Changes after Revascularization Surgery in Adult Patients with Ischemic Moyamoya Disease.
Article in Cerebrovascular diseases extra, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Pooled it
- Cognitive Deficits and Neuropsychological Assessment in Non-Revascularized Moyamoya Disease Patients: a Systematic Review.Neuropsychology review · 2026Review
- Preliminary analysis of long-term prognosis outcomes of modified extracranial-intracranial bypass reconstruction for adult ischemic moyamoya disease.Scientific reports · 2026Article
- Evaluating the role of graft angle on cerebral hemodynamics following direct cerebral bypass for moyamoya disease.PloS one · 2026Article
- Recovery of Intrinsic Cognitive Weakness in Successive Processing After Bypass Surgery for Pediatric Moyamoya Disease.Stroke (Hoboken, N.J.) · 2025Article
- Psychological outcomes and health-related quality of life changes in Chinese patients with moyamoya disease after revascularization.Frontiers in surgery · 2025Article
- Cognitive dysfunction in Moyamoya disease: latest developments and future directions.Frontiers in human neuroscience · 2024Review
- Neuropsychiatric Symptoms of Moyamoya Disease: Considerations for the Clinician.Neuropsychiatric disease and treatment · 2024Review
- Clinical Features and Treatment Outcomes in Patients in Their Twenties with Ischemic Moyamoya Disease.Cerebrovascular diseases extra · 2024Article
- Effect of the addition ofAnnals of nuclear medicine · 2023Article
- Association between White Matter Hyperintensities Burden and Cognitive Function in Adult Asymptomatic Moyamoya Disease.Journal of clinical medicine · 2023Article
- Three-dimensional pseudocontinuous arterial spin labeling perfusion imaging shows cerebral blood flow perfusion decline in attention-deficit/hyperactivity disorder children.Frontiers in psychiatry · 2023Article
- Safety and efficacy of remote ischemic conditioning in adult moyamoya disease patients undergoing revascularization surgery: a pilot study.Frontiers in neurology · 2023Article
- Changes in periventricular anastomosis after indirect revascularization surgery alone for adult patients with misery perfusion due to ischemic moyamoya disease.Neurosurgical review · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRevascularization surgery for adult moyamoya disease (MMD) with ischemic presentation changes cognitive function and prevents further cerebral ischemic events. Most studies however repeated neuropsychological evaluation within 1 year after surgery. Our previous prospective cohort study of adult patients with MMD with misery perfusion who underwent direct revascularization surgery showed cognitive improvement and decline in 31% and 44%, respectively, of the patients 2 months after surgery. The present prospective study aimed to elucidate the 5-year cognitive changes after direct revascularization surgery in adult patients with cerebral misery perfusion due to ischemic MMD by following the same patients.
methodsIn total, 31 patients were prospectively followed up for 5 years after direct revascularization surgery. Five types of neuropsychological tests were performed preoperatively, 2 months after surgery, and at the end of the 5-year follow-up. Cerebral blood flow (CBF) in the symptomatic cerebral hemisphere relative to that in the ipsilateral cerebellar hemisphere (hemispheric relative CBF [RCBF]) was measured using brain perfusion single-photon emission computed tomography preoperatively and at the end of the 5-year follow-up.
resultsBased on results of pre- and postoperative neuropsychological tests, 11, 10, and 10 patients showed cognitive improvement, no change in cognitive function, and cognitive decline, respectively, at the end of the 5-year follow-up. These ratios were not significantly different compared with those 2 months after surgery (cognitive improvement, no change in cognitive function, and cognitive decline in 10, 8, and 13 patients, respectively). Although hemispheric RCBF was significantly greater at the end of the 5-year follow-up than before surgery in patients with cognitive improvement (80.7 ± 6.1% vs. 92.9 ± 5.5%; p = 0.0033) and in those showing no change in cognitive function (85.6 ± 3.5 vs. 91.5 ± 5.2%; p = 0.0093), this value was significantly lower at the end of the 5-year follow-up than before surgery in patients with cognitive decline (83.8 ± 3.7 vs. 81.0 ± 5.8%; p = 0.0367).
conclusionOne-third of adult patients with cerebral misery perfusion due to ischemic MMD who underwent direct revascularization surgery exhibited cognitive improvement, and one-third exhibited decline at the end of the 5-year follow-up. The former and latter patients had increased and decreased CBF, respectively, in the affected cerebral hemisphere at the end of the 5-year follow-up compared with preoperative brain perfusion.
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