Evidence map›Paper›PMID 34808541›Full record

Observational studyAtherosclerosis2021

Heightened splenic and bone marrow uptake of

Nidhi H Patel, Michael T Osborne, Heather Teague, Philip Parel, Mariya Svirydava, Alexander V Sorokin, Meron Teklu, Grigory Manyak, Wunan Zhou, Carla Pantoja and 8 more

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Atherosclerosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 35 citations in OpenAlex.

  1. Cardiovascular imaging with total-body PET.The British journal of radiology · 2026
    Review
  2. [EJNMMI research · 2026
    Article
  3. Sharing a whole-/total-body [Scientific data · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Enhanced vascular inflammation in patients with advanced prostate cancer receiving hormone therapy.European journal of nuclear medicine and molecular imaging · 2025
    Article
  8. Article
  9. Article
  10. The spleen in ischaemic heart disease.Nature reviews. Cardiology · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Hyperpolarized [1-European radiology experimental · 2024
    Article
  18. Baseline [European journal of nuclear medicine and molecular imaging · 2024
    Article
  19. Article
  20. Heroin Use Is Associated With Vascular Inflammation in Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Nidhi H PatelNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Michael T OsborneCardiac Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Heather TeagueNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Philip ParelNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Mariya SvirydavaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Alexander V SorokinNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Meron TekluNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Grigory ManyakNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Wunan ZhouNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Carla PantojaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Colin ScottNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Martin P PlayfordNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Promita KapoorNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Justin A RodanteNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Andrew KeelNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Marcus ChenNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Ahmed TawakolCardiac Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Nehal N MehtaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: nehal.mehta@nih.gov.
National Institutes of Health · USHarvard University · US

Funding

The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease: A Multi-System PET/MRI StudyK23HL151909 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI OSBORNE, MICHAEL THOMAS · 2021 to 2025
$997k
NHLBI NIH HHS K23 HL151909
6 · The paper itself

Abstract

BACKGROUND AND

aimsPsoriasis is an immune-mediated inflammatory disease with increased risk of myocardial infarction. Preclinical studies in psoriasis models show an association between chronic inflammation and immune cell proliferation in the spleen and bone marrow (BM). We sought to test the hypothesis that splenic and BM

methodsMultimodality imaging and biomarker assays were performed in 240 participants (210 with psoriasis and 30 healthy). Splenic and BM uptake was obtained using

resultsSplenic and BM

conclusionsHeightened splenic and BM uptake of

Indexed as

AtherosclerosisPsoriasisBone MarrowFluorodeoxyglucose F18HumansInflammationPositron-Emission TomographyPositron Emission Tomography Computed TomographyRadiopharmaceuticalsSpleenFluorodeoxyglucose F18RadiopharmaceuticalsAtherosclerosisComputerized tomography (CT)Coronary artery diseaseInflammationNuclear cardiology and PET

Identifiers

PMID34808541
PMCPMC8723715
OpenAlexW3212238658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.