Evidence map›Paper›PMID 34808105›Full record

ArticleAmerican heart journal2022

Electronic alerts to initiate anticoagulation dialogue in patients with atrial fibrillation.

J Antonio Gutierrez, Ruff T Christian, Aaron W Aday, Lin Gu, Ryan D Schulteis, Lu Shihai, Michaela Petrini, Albert Y Sun, Rajesh V Swaminathan, Daniel R Katzenberger and 2 more

Open access · greenAbstract read
In one paragraph

Article in American heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

J Antonio GutierrezCardiology Section, Durham VA Medical Center, Durham, NC; Division of Cardiology, Duke University School of Medicine, Durham, NC; Duke Clinical Research Institute, Durham, NC. Electronic address: antonio.gutierrez@duke.edu.
Ruff T ChristianTIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Aaron W AdayVanderbilt Translational and Clinical Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Lin GuCardiology Section, Durham VA Medical Center, Durham, NC.
Ryan D SchulteisCardiology Section, Durham VA Medical Center, Durham, NC.
Lu ShihaiBoehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT.
Michaela PetriniBoehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT.
Albert Y SunCardiology Section, Durham VA Medical Center, Durham, NC; Division of Cardiology, Duke University School of Medicine, Durham, NC; Duke Clinical Research Institute, Durham, NC.
Rajesh V SwaminathanCardiology Section, Durham VA Medical Center, Durham, NC; Division of Cardiology, Duke University School of Medicine, Durham, NC; Duke Clinical Research Institute, Durham, NC.
Daniel R KatzenbergerCardiology Section, Durham VA Medical Center, Durham, NC.
Subhash BanerjeeCardiology Section, Veterans Affairs North Texas Health Care System, Dallas, TX; Division of Cardiology, University of Texas Southwestern Medical Center, Dallas TX.
Sunil V RaoCardiology Section, Durham VA Medical Center, Durham, NC; Division of Cardiology, Duke University School of Medicine, Durham, NC; Duke Clinical Research Institute, Durham, NC.
Duke University · USDurham VA Medical Center · USBoehringer Ingelheim (United States) · USBrigham and Women's Hospital · USVanderbilt University Medical Center · USVA North Texas Health Care System · US

Funding

The Vanderbilt Emergency Care Research Training ProgramK12HL133117 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STORROW, ALAN B · 2016 to 2020
$1.9M
The Impact of Thrombosis and Antithrombotic Therapy on Peripheral Artery DiseaseK23HL151871 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ADAY, AARON W. · 2021 to 2025
$927k
NHLBI NIH HHS K12 HL133117NHLBI NIH HHS K23 HL151871
6 · The paper itself

Abstract

importanceThe benefit of an electronic support system for the prescription and adherence to oral anticoagulation therapy among patients with atrial fibrillation (AF) and atrial flutter at heightened risk for of stroke and systemic thromboembolism is unclear.

objectiveTo evaluate the effect of a combined alert intervention and shared decision-making tool to improve prescription rates of oral anticoagulation therapy and adherence. DESIGN, SETTING, AND

participantsA prospective single arm study of 939 consecutive patients treated at a large tertiary healthcare system. EXPOSURES: An electronic support system comprising 1) an electronic alert to identify patients with AF or atrial flutter, a CHA MAIN OUTCOMES AND MEASURES: The primary endpoint was prescription rate of anticoagulation therapy. The secondary endpoint was adherence to anticoagulation therapy defined as medication possession ratio ≥ 80% during the 12 months of follow-up.

resultsBetween June 13, 2018 and August 31, 2018, the automated intervention identified and triggered a unique alert for 939 consecutive patients with AF or atrial flutter, a CHA CONCLUSION AND RELEVANCE: An electronic automated alert can successfully identify patients with AF and atrial flutter at high risk for stroke, increase oral anticoagulation prescription, and support high rates of adherence.

Indexed as

Atrial FibrillationStrokeAdministration, OralAnticoagulantsElectronicsHumansProspective StudiesRisk AssessmentRisk FactorsWarfarinAnticoagulantsWarfarin

Identifiers

PMID34808105
PMCPMC9713856
OpenAlexW3217685026

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.