ArticleBiophysical journal2021
Origin of gradients in lipid density and surface tension between connected lipid droplet and bilayer.
Article in Biophysical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- A conserved sequence insert of fibrillins is involved in plastoglobule association and lipid binding.Plant & cell physiology · 2026Article
- Solvent-Mediated Dewetting Principles for Cell-Sized Liposome Formation.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- ATG2 is a triglyceride transfer protein.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth.Nature structural & molecular biology · 2025Article
- Navigating lipid droplet proteins - part II: molecular mechanisms underlying ER-to-lipid droplet protein partitioning.Biochemical Society transactions · 2025Review
- Controlling lipid droplet dynamics via tether condensates.Nature chemical biology · 2025Article
- Steric repulsion counteracts ER-to-lipid droplet protein movement.Science advances · 2025Article
- The rheology and interfacial properties of biomolecular condensates.Biophysical reviews · 2025Review
- Dynamical modelling of lipid droplet formation suggests a key function of membrane phospholipids.The FEBS journal · 2025Article
- α/β hydrolase domain-containing protein 1 acts as a lysolipid lipase and is involved in lipid droplet formation.National science review · 2024Article
- Triacylglycerol-droplet-induced bilayer spontaneous curvature in giant unilamellar vesicles.Biophysical journal · 2024Article
- Hairpin protein partitioning from the ER to lipid droplets involves major structural rearrangements.Nature communications · 2024Article
- Tld1 is a regulator of triglyceride lipolysis that demarcates a lipid droplet subpopulation.The Journal of cell biology · 2024Article
- Monolayer/Bilayer Equilibrium of Phospholipids in Gel or Liquid States: Interfacial Adsorption via Monomer or Liposome Diffusion?Gels (Basel, Switzerland) · 2023Article
- LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy.Developmental cell · 2023Article
- Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation.Nature communications · 2023Article
- Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols.Nature communications · 2023Article
- Seipin-still a mysterious protein?Frontiers in cell and developmental biology · 2023Review
- Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome.The Journal of cell biology · 2022Article
- Capturing the Liquid-Crystalline Phase Transformation: Implications for Protein Targeting to Sterol Ester-Rich Lipid Droplets.Membranes · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We combined theory and experiments to depict physical parameters modulating the phospholipid (PL) density and tension equilibrium between a bilayer and an oil droplet in contiguity. This situation is encountered during a neutral lipid (NL) droplet formation in the endoplasmic reticulum. We set up macroscopic and microscopic models to uncover free parameters and the origin of molecular interactions controlling the PL densities of the droplet monolayer and the bilayer. The established physical laws and predictions agreed with experiments performed with droplet-embedded vesicles. We found that the droplet monolayer is always by a few percent (∼10%) less packed with PLs than the bilayer. Such a density gradient arises from PL-NL interactions on the droplet, which are lower than PL-PL trans interactions in the bilayer, i.e., interactions between PLs belonging to different leaflets of the bilayer. Finally, despite the pseudo-surface tension for the water/PL acyl chains in the bilayer being higher than the water/NL surface tension, the droplet monolayer always has a higher surface tension than the bilayer because of its lower PL density. Thus, a PL density gradient is mandatory to maintain the mechanical and thermodynamic equilibrium of the droplet-bilayer continuity. Our study sheds light on the origin of the molecular interactions responsible for the unique surface properties of lipid droplets compared with cellular bilayer membranes.
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