Evidence map›Paper›PMID 34808078›Full record

ArticleEmerging infectious diseases2021

Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018.

Neeltje van Doremalen, Michael Letko, Robert J Fischer, Trenton Bushmaker, Jonathan Schulz, Claude K Yinda, Stephanie N Seifert, Nam Joong Kim, Maged G Hemida, Ghazi Kayali and 13 more

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Neeltje van Doremalen
Michael Letko
Robert J Fischer
Trenton Bushmaker
Jonathan Schulz
Claude K Yinda
Stephanie N Seifert
Nam Joong Kim
Maged G Hemida
Ghazi Kayali
Wan Beom Park
Ranawaka A P M Perera
Azaibi Tamin
Natalie J Thornburg
Suxiang Tong
Krista Queen
Maria D van Kerkhove
Young Ki Choi
Myoung-Don Oh
Abdullah M Assiri
Malik Peiris
Susan I Gerber
Vincent J Munster

Funding

Virus Ecology UnitZIAAI001179 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MUNSTER, VINCENT · 2013 to 2025
$24.3M
Intramural NIH HHS ZIA AI001179
6 · The paper itself

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) infects humans and dromedary camels and is responsible for an ongoing outbreak of severe respiratory illness in humans in the Middle East. Although some mutations found in camel-derived MERS-CoV strains have been characterized, most natural variation found across MERS-CoV isolates remains unstudied. We report on the environmental stability, replication kinetics, and pathogenicity of several diverse isolates of MERS-CoV, as well as isolates of severe acute respiratory syndrome coronavirus 2, to serve as a basis of comparison with other stability studies. Although most MERS-CoV isolates had similar stability and pathogenicity in our experiments, the camel-derived isolate C/KSA/13 had reduced surface stability, and another camel isolate, C/BF/15, had reduced pathogenicity in a small animal model. These results suggest that although betacoronaviruses might have similar environmental stability profiles, individual variation can influence this phenotype, underscoring the need for continual global viral surveillance.

Indexed as

COVID-19Middle East Respiratory Syndrome CoronavirusAerosolsAnimalsCamelusHumansSARS-CoV-2VirulenceZoonosesAerosolscoronavirusMERS-CoVMiddle East respiratory syndrome coronaviruspathogenicityrespiratory infectionsSARS-CoV-2severe acute respiratory syndrome coronavirus 2strainssurface‒aerosol stabilityviruseszoonoses

Identifiers

PMID34808078
PMCPMC8632154
OpenAlexW3216687847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.