Evidence map›Paper›PMID 34808036›Full record

Trial reportMolecular nutrition & food research2022

Comparative Analysis of the Effects of Fish Oil and Fenofibrate on Plasma Metabolomic Profiles in Overweight and Obese Individuals.

Charlotte C J R Michielsen, Roland W J Hangelbroek, Marjolijn C E Bragt, Elwin R Verheij, Suzan Wopereis, Ronald P Mensink, Lydia A Afman

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular nutrition & food research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Charlotte C J R MichielsenNutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Stippeneng 4, Wageningen, the Netherlands.ORCID 0000-0003-1018-7721
Roland W J HangelbroekNutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Stippeneng 4, Wageningen, the Netherlands.
Marjolijn C E BragtNUTRIM School of Nutrition and Translational Research in Metabolism, Department of Nutrition and Movement Sciences, Maastricht University Medical Centre+, P.O. Box 616, Maastricht, 6200 MD, the Netherlands.
Elwin R VerheijUnit Healthy Living, Netherlands Organisation for Applied Scientific Research (TNO), Zeist, 3704 HE, the Netherlands.
Suzan WopereisUnit Healthy Living, Netherlands Organisation for Applied Scientific Research (TNO), Zeist, 3704 HE, the Netherlands.
Ronald P MensinkNUTRIM School of Nutrition and Translational Research in Metabolism, Department of Nutrition and Movement Sciences, Maastricht University Medical Centre+, P.O. Box 616, Maastricht, 6200 MD, the Netherlands.
Lydia A AfmanNutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Stippeneng 4, Wageningen, the Netherlands.
Wageningen University & Research · NLMaastricht University Medical Centre · NLNetherlands Organisation for Applied Scientific Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

scopeThe drug fenofibrate and dietary fish oils can effectively lower circulating triglyceride (TG) concentrations. However, a detailed comparative analysis of the effects on the plasma metabolome is missing. METHODS AND

resultsTwenty overweight and obese subjects participate in a double-blind, cross-over intervention trial and receive in a random order 3.7 g day

conclusionFenofibrate and fish oil reduce several saturated TG-species markedly. These reductions have been associated with a decreased risk for developing cardiovascular disease (CVD). Interestingly, fish oil consumption increases several unsaturated lipid species, which have also been associated with a reduced CVD risk. Altogether, this points towards the power of fish oil to change the plasma lipid metabolome in a potentially beneficial way.

Indexed as

Fatty Acids, Omega-3FenofibrateDouble-Blind MethodFish OilsHumansObesityOverweightTriglyceridesFatty Acids, Omega-3FenofibrateFish OilsTriglyceridesclinical trialhumanlipidomicsnutrigenomicsperoxisome proliferator-activated receptor α

Identifiers

PMID34808036
PMCPMC9286410
OpenAlexW3216411078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.