Evidence map›Paper›PMID 34808031›Full record

ReviewAdvanced healthcare materials2022

Engineering Tissues of the Central Nervous System: Interfacing Conductive Biomaterials with Neural Stem/Progenitor Cells.

Rebecca D Bierman-Duquette, Gevick Safarians, Joyce Huang, Bushra Rajput, Jessica Y Chen, Ze Zhong Wang, Stephanie K Seidlits

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced healthcare materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  9. Peptide Electrostatic Modulation Directs Human Neural Cell Fate.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rebecca D Bierman-DuquetteDepartment of Bioengineering, University of California Los Angeles, Los Angeles, 90095, USA.
Gevick SafariansDepartment of Bioengineering, University of California Los Angeles, Los Angeles, 90095, USA.
Joyce HuangDepartment of Bioengineering, University of California Los Angeles, Los Angeles, 90095, USA.
Bushra RajputDepartment of Bioengineering, University of California Los Angeles, Los Angeles, 90095, USA.
Jessica Y ChenDepartment of Bioengineering, University of California Los Angeles, Los Angeles, 90095, USA.
Ze Zhong WangDepartment of Bioengineering, University of California Los Angeles, Los Angeles, 90095, USA.
Stephanie K SeidlitsDepartment of Bioengineering, University of California Los Angeles, Los Angeles, 90095, USA.ORCID 0000-0003-3881-7166
University of California, Los Angeles · US

Funding

Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.UH3TR003148 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ASHAMMAKHI, NUREDDIN, MAIDMENT, NIGEL T · 2022 to 2024
$2.4M
Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.UG3TR003148 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ASHAMMAKHI, NUREDDIN, KHADEMHOSSEINI, ALI · 2019 to 2021
$2.1M
NCATS NIH HHS UG3 TR003148NCATS NIH HHS UH3 TR003148
6 · The paper itself

Abstract

Conductive biomaterials provide an important control for engineering neural tissues, where electrical stimulation can potentially direct neural stem/progenitor cell (NS/PC) maturation into functional neuronal networks. It is anticipated that stem cell-based therapies to repair damaged central nervous system (CNS) tissues and ex vivo, "tissue chip" models of the CNS and its pathologies will each benefit from the development of biocompatible, biodegradable, and conductive biomaterials. Here, technological advances in conductive biomaterials are reviewed over the past two decades that may facilitate the development of engineered tissues with integrated physiological and electrical functionalities. First, one briefly introduces NS/PCs of the CNS. Then, the significance of incorporating microenvironmental cues, to which NS/PCs are naturally programmed to respond, into biomaterial scaffolds is discussed with a focus on electrical cues. Next, practical design considerations for conductive biomaterials are discussed followed by a review of studies evaluating how conductive biomaterials can be engineered to control NS/PC behavior by mimicking specific functionalities in the CNS microenvironment. Finally, steps researchers can take to move NS/PC-interfacing, conductive materials closer to clinical translation are discussed.

Indexed as

Biocompatible MaterialsNeural Stem CellsCentral Nervous SystemElectric ConductivityTissue EngineeringBiocompatible Materialscell-material interfacescentral nervous system degenerationconductive biomaterialsneural engineeringneural stem/progenitor cellsregenerative medicine

Identifiers

PMID34808031
PMCPMC8986557
OpenAlexW3216183955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.