ArticleThe EMBO journal1987
Upstream regions of the hamster desmin and vimentin genes regulate expression during in vitro myogenesis.
Article in The EMBO journal, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 71 citations in OpenAlex.
- Adapting cytoskeleton-mitochondria patterning with myocyte differentiation by promyogenic PRR33.Cell death and differentiation · 2025Article
- Titin expression as an early indication of heart and skeletal muscle differentiation in vitro. Developmental re-organisation in relation to cytoskeletal constituents.Journal of muscle research and cell motility · 1996Article
- The basic helix-loop-helix protein upstream stimulating factor regulates the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements.Molecular and cellular biology · 1994Article
- An E box in the desmin promoter cooperates with the E box and MEF-2 sites of a distal enhancer to direct muscle-specific transcription.The EMBO journal · 1994Article
- Ectopic synthesis of epidermal cytokeratins in pancreatic islet cells of transgenic mice interferes with cytoskeletal order and insulin production.The Journal of cell biology · 1993Article
- Regulation of the mouse desmin gene: transactivated by MyoD, myogenin, MRF4 and Myf5.Nucleic acids research · 1993Article
- Sodium butyrate inhibits myogenesis by interfering with the transcriptional activation function of MyoD and myogenin.Molecular and cellular biology · 1992Article
- Desmin/vimentin intermediate filaments are dispensable for many aspects of myogenesis.The Journal of cell biology · 1991Article
- A negative element involved in vimentin gene expression.Molecular and cellular biology · 1990Article
- Epithelial-specific keratin gene expression: identification of a 300 base-pair controlling segment.Nucleic acids research · 1990Article
- Molecular and functional analysis of the muscle-specific promoter region of the Duchenne muscular dystrophy gene.Molecular and cellular biology · 1990Article
- A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.Molecular and cellular biology · 1989Article
- Muscle creatine kinase sequence elements regulating skeletal and cardiac muscle expression in transgenic mice.Molecular and cellular biology · 1989Article
- Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.Molecular and cellular biology · 1989Article
- Transgenic expression of the muscle-specific intermediate filament protein desmin in nonmuscle cells.The Journal of cell biology · 1989Article
- Enhancer elements directing cell-type-specific expression of cytokeratin genes and changes of the epithelial cytoskeleton by transfections of hybrid cytokeratin genes.The EMBO journal · 1989Article
- Tissue-specific expression of a vimentin--desmin hybrid gene in transgenic mice.The EMBO journal · 1988Article
- SV40 large T antigen-induced inhibition of terminal differentiation of primary skeletal muscle cells is associated with a block in the expression of MyoD and myogenin.Molecular biology reportsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Varying lengths of the hamster desmin and vimentin promoter regions were fused to the bacterial chloramphenicol acetyl-transferase gene. These constructs were transfected into two different myogenic cell lines, T984 and C2C12. In both cell lines an increase in endogenous desmin expression takes place upon myogenesis. A region between -89 and +25 bp relative to the desmin transcription initiation site directs high-level tissue- and stage-specific expression upon in vitro myogenesis. At the myoblast stage, C2C12 cells appeared to express both desmin and vimentin, whereas in T984 myoblasts only vimentin expression was detected. Although vimentin is expressed during all stages of myogenesis, a strong decrease in vimentin expression occurs during differentiation of C2C12 cells. Vimentin--CAT constructs followed the endogenous expression pattern, showing that this down-regulation is mediated by 5' flanking sequences. Vimentin promoter activity is modulated by at least two separate regions, both in myogenic and in non-myogenic cell lines.
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