Evidence map›Paper›PMID 34807889›Full record

ReviewJournal of the American Academy of Orthopaedic Surgeons. Global research & reviews2021

Statistical Fragility of Surgical Clinical Trials in Orthopaedic Trauma.

Lynn Ann Forrester, Kyle L McCormick, Lisa Bonsignore-Opp, Liana J Tedesco, Eric S Baranek, Eugene S Jang, Wakenda K Tyler

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Assessment of 30 Years of Randomized Controlled Trials inOrthopaedic journal of sports medicine · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lynn Ann ForresterFrom the Department of Orthopedic Surgery (Dr. Forrester, Dr. Tedesco, Dr. Baranek, Dr. Jang, and Dr. Tyler), Columbia University Irving Medical Center and the Columbia University Vagelos College of Physicians and Surgeons (Dr. McCormick and Bonsignore-Opp), New York, NY.ORCID 0000-0002-8795-6173
Kyle L McCormickORCID 0000-0002-0322-6852
Lisa Bonsignore-OppORCID 0000-0002-5463-7096
Liana J TedescoORCID 0000-0001-5927-4469
Eric S Baranek
Eugene S Jang
Wakenda K TylerORCID 0000-0002-8837-9240

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Fragility Index (FI) and the Fragility Quotient (FQ) are powerful statistical tools that can aid clinicians in assessing clinical trial results. The purpose of this study was to use the FI and FQ to evaluate the statistical robustness of widely cited surgical clinical trials in orthopaedic trauma.

methodsWe performed a PubMed search for orthopaedic trauma clinical trials in high-impact orthopaedics-focused journals and calculated the FI and FQ for all identified dichotomous, categorical outcomes.

resultsWe identified 128 studies with 545 outcomes. The median FI was 5, and the median FQ was 0.0482. For statistically significant and not statistically significant outcomes, the median FIs were 3 and 5, and the mean FQs were 0.0323 and 0.0526, respectively. The FI was greater than the number of patients lost to follow-up in most outcomes.

conclusionsThe orthopaedic trauma literature is of equal or higher quality than research in other orthopaedic subspecialties, suggesting that other orthopaedic subspecialties may benefit from modeling their clinical trials after those in orthopaedic trauma.

Indexed as

Orthopedic ProceduresOrthopedicsHumans

Identifiers

PMID34807889
PMCPMC8608260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.