ArticleAdvances in experimental medicine and biology2022
Hepatic Glucose Metabolism and Its Disorders in Fish.
Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Beyond Probiotics: Postbiotics for Healthy Aquaculture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Article
- Histochemical and Semi-Quantitative Evidence of Dimoxystrobin-Induced Liver Extracellular Matrix Remodelling in Adult Zebrafish.Journal of xenobiotics · 2026Article
- Analysis of hepatic and serum responses to acute cold stress in juvenile yellowfin tuna Thunnus albacares (Bonnaterre 1788).Journal of fish biology · 2026Article
- Evaluation of the Health Status of Largemouth Bass (Animals : an open access journal from MDPI · 2026Article
- Effects of Vitamin E on Growth Performance, Biochemical Indices, Antioxidant Capacity, and Ovarian Development in Female Chinese Sturgeon (Animals : an open access journal from MDPI · 2026Article
- Dietary N-Carbamylglutamate Partially Alleviates High-Starch-Induced Hepatic Oxidative Stress and Glycogenic Hepatopathy in Largemouth Bass (Antioxidants (Basel, Switzerland) · 2026Article
- Chronic Thermal Stress During Early Zebrafish (Danio rerio) Development Induces Morphological, Molecular, and Liver Histopathological Changes.Fish physiology and biochemistry · 2026Article
- High Ratio of Dietary Palmitic Acid to DHA + EPA Induces Glucose Metabolic Disorder Through Endocrine and Transcriptional Regulation in Large Yellow Croaker (Metabolites · 2026Article
- Article
- Nutritional Intervention of Zinc on Metabolic Disorders Induced by High-Starch Diets in Largemouth Bass (Aquaculture nutrition · 2026Article
- Effects of Replacing Fishmeal With Antarctic Krill Meal on Nutrient Deposition, Metabolism, and Immunity in Silver Pomfret (Aquaculture nutrition · 2026Article
- Epigallocatechin-3-gallate supplementation regulates glucose redistribution through its potential endogenous receptor in grass carp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Mechanisms of high-glucose-induced mitochondrial damage and glycolipid accumulation in largemouth bass.Journal of animal science and biotechnology · 2025Article
- Effects of Dietary Protease Levels on Growth Performance, Feeding Regulation, Glucose and Lipid Metabolism, and Endogenous Protease Secretion in Chinese Perch (Animals : an open access journal from MDPI · 2025Article
- Functional Feed for Tilapia: Exploring the Benefits ofBiology · 2025Article
- Effects of Nitrite Stress on Growth, Glycolipid Metabolism, and Hepatic Metabolome in Spotted Seabass (Animals : an open access journal from MDPI · 2025Article
- Rainbow Trout (International journal of molecular sciences · 2025Article
- Appropriate Fat Supplementation in High-Starch Diets Involved in the Modification of Fatty Acids Profile, Amino Acids Composition, and Antioxidant Capacity of Adult Nile Tilapia (Aquaculture nutrition · 2025Article
- Comparative Transcriptome Analysis Reveals the Impact of a High-Fat Diet on Hepatic Metabolic Function in Tilapia (Animals : an open access journal from MDPI · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbohydrate, which is the most abundant nutrient in plant-sourced feedstuffs, is an economically indispensable component in commercial compound feeds for fish. This nutrient can enhance the physical quality of diets and allow for pellet expansion during extrusion. There is compelling evidence that an excess dietary intake of starch causes hepatic disorders, thereby further reducing the overall food consumption and growth performance of fish species. Among the severe metabolic disturbances are glycogenic hepatopathy (hepatomegaly caused by the excessive accumulation of glycogen in hepatocytes) and hepatic steatosis (the accumulation of large vacuoles of triacylglycerols in hepatocytes). The development of those disorders is mainly due to the limited ability of fish to oxidize glucose and control blood glucose concentration. The prolonged elevations of blood glucose increase glucose intake by the liver, and excess glucose is stored either as glycogen through glycogenesis in hepatocytes or as triglycerides via lipogenesis in tissues, depending on the species. In some fish species (e.g., largemouth bass), the liver has a low ability to regulate glycolysis, gluconeogenesis, and glycogen breakdown in response to high starch intake. For most species of fish, the liver size increases with lipid or glycogen accumulation when they have a high starch intake. It is a challenge to develop the same set of diagnostic criteria for all fish species as their physiology or metabolic patterns differ. Although glycogenic hepatopathy appears to be a common disease in carnivorous fish, it has been under-recognized in many studies. As a result, understanding these diseases and their pathogeneses in different fish species is crucial for manufacturing cost-effective pellet diets to promote the health, growth, survival, and feed efficiency of fish in future.
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