ReviewAdvances in experimental medicine and biology2022
Phosphate, Calcium, and Vitamin D: Key Regulators of Fetal and Placental Development in Mammals.
Review in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- FGF23 level in poultry chicken, a systematic review and meta-analysis.Frontiers in physiology · 2023Pooled it
- Prenatal Aflatoxin BToxins · 2026Review
- The Immunological Role of Vitamin D in Primary Immunodeficiencies: A Narrative Review of the Current Literature.Biomedicines · 2026Review
- Maternal-infant vitamin D coupling and neonatal hypocalcemia: a six-year cohort integrating preterm risk, onset timing, and pandemic effects.BMC pediatrics · 2026Article
- Pregnancy Vitamin D Deficiency Prevalence and Adverse Birth Outcomes in Mazandaran, a Province of Iran: A Cross-Sectional Study.Journal of pregnancy · 2026Article
- UVB Light as a Source of Vitamin D for Indoor-Housed Gestating Sows.Animals : an open access journal from MDPI · 2025Article
- A head start: The relationship of placental factors to craniofacial and brain development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Review
- Characterization of the expression of XPR1 in ovine utero-placental tissues.Reproduction (Cambridge, England) · 2025Article
- Characterization of TNSALP expression and activity in porcine utero-placental tissues.Reproduction & fertility · 2025Article
- Reducing early pregnancy loss with vitamin DJournal of clinical biochemistry and nutrition · 2025Article
- Gaps in maternal-fetal interface rejection response: chronic histiocytic intervillositis.Frontiers in immunology · 2025Review
- Exogenous progesterone supplementation: a strategy to enhance conceptus development in sheep and pigs?Reproduction & fertility · 2025Review
- The efficacy of calcium and vitamin D3 supplementation in improving pregnancy and neonatal outcomes.Frontiers in pediatrics · 2025Article
- Iron infusion in pregnancy and dental dysplasia in children-is there a link?Frontiers in pediatrics · 2025Article
- Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms and five related serum molecular levels in 2587 patients: Associated differentially with adverse pregnancy.Molecular biology reports · 2024Article
- Article
- Progesterone regulates tissue non-specific alkaline phosphatase (TNSALP) expression and activity in ovine utero-placental tissues.Journal of animal science and biotechnology · 2024Article
- High prevalence of hypovitaminosis D3 among pregnant women in central Iran: correlation with newborn vitamin D3 levels and negative association with gestational age.Obstetrics & gynecology science · 2023Article
- Phosphate, calcium, and vitamin D signaling, transport, and metabolism in the endometria of cyclic ewes.Journal of animal science and biotechnology · 2023Article
- Prevalence of 25-Hydroxyvitamin D (Vitamin D) Deficiency in a Group of Infertile Women from Baghdad City.Biochemistry research international · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Normal calcium and bone homeostasis in the adult is virtually fully explained by the interactions of several key regulatory hormones, including parathyroid hormone, 1,25 dihydroxy vitamin D3, fibroblast growth factor-23, calcitonin, and sex steroids (estradiol and testosterone). In utero, bone and mineral metabolism is regulated differently from the adult. During development, it is the placenta and not the fetal kidneys, intestines, or skeleton that is the primary source of minerals for the fetus. The placenta is able to meet the almost inexhaustible needs of the fetus for minerals by actively driving the transport of calcium and phosphorus from the maternal circulation to the growing fetus. These fundamentally important minerals are maintained in the fetal circulation at higher concentrations than those in maternal blood. Maintenance of these inordinately higher fetal levels is necessary for the developing skeleton to accrue sufficient minerals by term. Importantly, in livestock species, prenatal mineralization of the skeleton is crucial for the high levels of offspring activity soon after birth. Calcium is required for mineralization, as well as a plethora of other physiological functions. Placental calcium and phosphate transport are regulated by several mechanisms that are discussed in this review. It is clear that phosphate and calcium metabolism is intimately interrelated and, therefore, placental transport of these minerals cannot be considered in isolation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.