Evidence map›Paper›PMID 34807408›Full record

ArticleHuman cell2022

Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis.

Hao Meng, Lian-Kun Sun, Jing Su, Wan-Yu Yan, Yao Jin, Xin Luo, Xian-Rui Jiang, Hong-Lei Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Sirtuin-3: A potential target for treating several types of brain injury.Frontiers in cell and developmental biology · 2023
    Review
  8. Mitochondria in neurodegeneration.Current opinion in physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hao MengDepartment of Radiotherapy, The Second Hospital of Jilin University, Changchun, China.
Lian-Kun SunDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Jing SuDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Wan-Yu YanDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Yao JinDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Xin LuoDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Xian-Rui JiangDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Hong-Lei WangDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China. wanghongl@jlu.edu.cn.
Jilin University · CNFirst Hospital of Jilin University · CNSecond Affiliated Hospital of Jilin University · CN

Funding

Foundation of Jilin Provincial Department of Finance JLSCZD 2019-015Foundation of Jilin Provincial Department of Finance JLSCZD2019-015Hospital Youth Foundation of the 1st Hospital of Jilin University JDYY102019018Industrial technology research and development project of Jilin development and Reform Commission 2020C034-4Jilin Provincial Industrial Innovation Project 2018C052-7Jilin Provincial Research Foundation for the Development of Science and Technology Projects 20170623021TCJilin Provincial Research Foundation for the Development of Science and Technology Projects 20180623024TCJilin Provincial Research Foundation for the Development of Science and Technology Projects 20190201152JCJilin Provincial Research Foundation for the Development of Science and Technology Projects 20191004004TCthe following funding: National Natural Science Foundation of China 81472419the following funding: National Natural Science Foundation of China 81772794
6 · The paper itself

Abstract

This study is to investigate the underlying mechanisms of mitochondrial quality control (MQC) regulated by HtrA2/Omi during ischemia/reperfusion (I/R). We utilized the mnd2 mouse model, which has a missense mutation in HtrA2/Omi, to investigate the HtrA2/Omi regulation in mitochondria after I/R injury in the cerebral cortex. Compared to homozygous (HtrA2

Indexed as

AnimalsCellular ReprogrammingCerebral CortexDisease Models, AnimalHigh-Temperature Requirement A Serine Peptidase 2Hypoxia, BrainMice, TransgenicMitochondriaPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaReperfusion InjurySirtuin 3Uncoupling Protein 2High-Temperature Requirement A Serine Peptidase 2Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseSirt3 protein, mouseSirtuin 3Ucp2 protein, mouseUncoupling Protein 2GenipinHtrA2/OmiIschemia–reperfusion injuryMitochondriaUCP2-SIRT3-PGC1 axis

Identifiers

PMID34807408
OpenAlexW3215599618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.