ArticlePituitary2022
A study on clinical outcomes of Rathke's cleft cyst in patients managed conservatively.
Article in Pituitary, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Spontaneous regression of Rathke's cleft cysts: MRI predictors and temporal dynamics.Neuroradiology · 2026Article
- High recurrence of rathke's cleft cysts with anterior-Inferior pituitary displacement despite standard surgical approaches.Pituitary · 2025Article
- Rathke's cleft cyst: From history to molecular genetics.Reviews in endocrine & metabolic disorders · 2025Review
- Conservative Management of Symptomatic Rathke Cleft Cyst With Recurrent Inflammatory Remission.JCEM case reports · 2025Article
- Spontaneous regression of Rathke's cleft cysts with conservative management: patient series.Journal of neurosurgery. Case lessons · 2024Article
- Long-term outcome of surgically treated and conservatively managed Rathke cleft cysts.Acta neurochirurgica · 2024Article
- Letter to the editor: long-term outcomes and potential predictive recurrence factors after endonasal endoscopic surgical treatment of symptomatic rathke's cleft cysts.Neurosurgical review · 2024Article
- Long-term outcomes and potential predictive recurrence factors after endonasal endoscopic surgical treatment of symptomatic Rathke's cleft cysts.Neurosurgical review · 2024Article
- Suggestion of Follow-Up Period in Nonfunctioning Pituitary Incidentaloma Based on MRI Characteristics.Brain tumor research and treatment · 2024Article
- Incidence and factors associated with the recurrence of Rathke's cleft cyst after surgery: A systematic review and meta-analysis.Frontiers in surgery · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe primary objective was to investigate the clinical presentation, hormonal dysfunction, imaging characteristics and natural history of RCCs that were managed conservatively. Secondary objective was to identify factors associated with cyst progression.
methodsA retrospective review of patients with the clinical diagnosis of RCC-identified from word search from radiology reports that were followed up from January 1999 to March 2019 was performed. The demographics, clinical data, radiological features and outcomes were reviewed and analyzed.
results105 patients were identified with a median follow up of 6 years. 68 patients (64.8%) were managed conservatively from diagnosis till last follow up while 37 patients (35.2%) underwent surgery, with 26 operated at time of diagnosis and 11 operated upon monitoring. For patients managed conservatively from diagnosis till last follow up, incidental finding was the most common presentation. 19.1% had either one or more axes of hormonal dysfunction, with hypogonadism and hypocortisolemia being the commonest ones. Imaging features were variable. 66.2% of patients had T2W hyperintensity on MRI. Pathognomonic feature of intracystic nodule was present in only 14.7% of patients. Among the 79 patients with repeated MRI imaging (68 from conservative group and 11 from surgical group), 32.9% of patients developed cyst progression while 67.1% had either static disease or regression in size of RCC. Median time to progression of cyst was 14 months. Longer median follow up duration and presence of pituitary stalk displacement at presentation were associated with cyst progression. Only one patient developed new endocrine dysfunction.
conclusion2/3 of the RCCs had static disease or even regression in the size of the cyst. They rarely gave rise to additional endocrine dysfunction by adopting observant approach. Cyst progression was demonstrated in 1/3 of patients. Conservative treatment remained a reasonable treatment for patients without significant symptoms.
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