ArticleTranslational vision science & technology2021
Automated Image Segmentation of the Corneal Endothelium in Patients With Fuchs Dystrophy.
Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Current Applications of Artificial Intelligence for Fuchs Endothelial Corneal Dystrophy: A Systematic Review.Translational vision science & technology · 2025Pooled it
- Recent advances in corneal specular microscopy image analysis through artificial intelligence.PLOS digital health · 2026Review
- Longitudinal Study ofMedical sciences (Basel, Switzerland) · 2026Article
- Deep Learning Analysis of Widefield Cornea Endothelial Imaging in Fuchs Dystrophy.Ophthalmology science · 2026Article
- Artificial Intelligence Application in Cornea and External Diseases.Diagnostics (Basel, Switzerland) · 2025Review
- Artificial Intelligence in Ophthalmology: Practical Applications, Subspecialty Evidence and Real-World Deployment.Cureus · 2025Review
- Diagnostic Performance of Publicly Available Large Language Models in Corneal Diseases: A Comparison with Human Specialists.Diagnostics (Basel, Switzerland) · 2025Article
- Deep learning-assisted widefield endothelial imaging in Descemet membrane endothelial keratoplasty.Frontiers in medicine · 2025Article
- Artificial intelligence in corneal diseases: A narrative review.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2024Review
- Article
- Deep learning for detection of Fuchs endothelial dystrophy from widefield specular microscopy imaging: a pilot study.Eye and vision (London, England) · 2024Article
- Applications of Imaging Technologies in Fuchs Endothelial Corneal Dystrophy: A Narrative Literature Review.Bioengineering (Basel, Switzerland) · 2024Review
- Article
- Big data in corneal diseases and cataract: Current applications and future directions.Frontiers in big data · 2023Review
- Corneal endothelium assessment in specular microscopy images with Fuchs' dystrophy via deep regression of signed distance maps.Biomedical optics express · 2023Article
- Artificial intelligence and corneal diseases.Current opinion in ophthalmology · 2022Review
- DenseUNets with feedback non-local attention for the segmentation of specular microscopy images of the corneal endothelium with guttae.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To perform segmentation of specular microscopy (SM) images of the corneal endothelium for comparing average perimeter length (APL) between Fuchs endothelial corneal dystrophy (FECD) patients and healthy subjects. Methods: A retrospective review of clinical records of FECD patients and those with healthy endothelium was carried out to collect images of the endothelium. The images were segmented by modified U-Net, a deep learning architecture, followed by the Watershed algorithm to resolve merged cell borders (<5%). The segmented images were analyzed for endothelial cell density (ECDUW) and APL. Results: The combination of the U-Net and Watershed algorithm, referred to as the UW approach, enabled a complete segmentation of the endothelium. In healthy, ECDUW was close to estimates by SM and manual segmentation (31 subjects; P > 0.1). However, in FECD, ECDUW was closer to estimates by manual segmentation but not by SM (27 patients; P < 0.001). ECDUW in FECD (2547 ± 499 cells/mm2; 60 patients) was smaller compared to that in the healthy (2713 ± 401 cells/mm2; 70 subjects) (P < 0.001). APL in the healthy was 66.87 ± 7.68 µm/cell (70 subjects), but it increased with %Guttae in FECD (56.60-195.30 µm/cell; 60 patients) (P < 0.0001). Conclusions: The UW approach is precise for the segmentation of SM images from the healthy and FECD. Our analysis has revealed that APL increases with %Guttae. Translational Relevance: The average perimeter length of the corneal endothelium, which represents the length of the paracellular pathway for fluid flux into the stroma, is increased in Fuchs dystrophy.
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