Evidence map›Paper›PMID 34806846›Full record

ArticleChemistryOpen2021

The Effect of the Side Chain on Gelation Properties of Bile Acid Alkyl Amides.

Riikka T Kuosmanen, Khai-Nghi Truong, Kari T Rissanen, Elina I Sievänen

Abstract read
In one paragraph

Article in ChemistryOpen, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Riikka T KuosmanenDepartment of Chemistry, University of Jyvaskyla, P.O. Box 35, 40014, Jyväskylä, Finland.
Khai-Nghi TruongDepartment of Chemistry, University of Jyvaskyla, P.O. Box 35, 40014, Jyväskylä, Finland.ORCID 0000-0001-9764-7350
Kari T RissanenDepartment of Chemistry, University of Jyvaskyla, P.O. Box 35, 40014, Jyväskylä, Finland.ORCID 0000-0002-7282-8419
Elina I SievänenDepartment of Chemistry, University of Jyvaskyla, P.O. Box 35, 40014, Jyväskylä, Finland.ORCID 0000-0003-3217-0082

Funding

University of Jyvaskyla
6 · The paper itself

Abstract

Six bile acid alkyl amide derivatives were studied with respect to their gelation properties. The derivatives were composed of three different bile acids with hexyl or cyclohexyl side chains. The gelation behaviour of all six compounds were studied for 36 solvents with varying polarities. Gelation was observed mainly in aromatic solvents, which is characteristic for bile-acid-based low molecular weight gelators. Out of 108 bile acid-solvent combinations, a total of 44 gel systems were formed, 28 of which from lithocholic acid derivatives, only two from deoxycholic acid derivatives, and 14 from cholic acid derivatives. The majority of the gel systems were formed from bile acids with hexyl side chains, contrary to the cyclohexyl group, which seems to be a poor gelation moiety. These results indicate that the spatial demand of the side chain is the key feature for the gelation properties of the bile acid amides.

Indexed as

AmidesBile Acids and SaltsCholic AcidGelsLithocholic AcidAmidesBile Acids and SaltsCholic AcidGelsLithocholic Acidbile acid amidesintermolecular interactionssolvent influencesupramolecular gelsX-ray crystallography

Identifiers

PMID34806846
PMCPMC8607806

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.